Flowometry in optical coherence tomography for analyte level estimation
First Claim
1. A method comprising:
- receiving, from an optical coherence tomography apparatus, an intensity data measurement for a region of tissue;
passing the intensity data measurement through a first frequency band filter having a first bandwidth to produce a first output;
passing the intensity data measurement through a second frequency band filter having a second bandwidth that is wider than the first bandwidth to produce a second output;
determining, by a processor, an indication of fluid flow in the region of tissue by comparing the first output and the second output; and
in response to determining a positive indication of fluid flow in the region of tissue, determining, by the processor, a blood analyte measurement based on at least some of the intensity data measurement.
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Abstract
Optical coherence tomography (herein “OCT”) based analyte monitoring systems are disclosed. In one aspect, techniques are disclosed that can identify fluid flow in vivo (e.g., blood flow), which can act as a metric for gauging the extent of blood perfusion in tissue. For instance, if OCT is to be used to estimate the level of an analyte (e.g., glucose) in tissue, a measure of the extent of blood flow can potentially indicate the presence of an analyte correlating region, which would be suitable for analyte level estimation with OCT. Another aspect is related to systems and methods for scanning multiple regions. An optical beam is moved across the surface of the tissue in two distinct manners. The first can be a coarse scan, moving the beam to provide distinct scanning positions on the skin. The second can be a fine scan where the beam is applied for more detailed analysis.
1076 Citations
18 Claims
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1. A method comprising:
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receiving, from an optical coherence tomography apparatus, an intensity data measurement for a region of tissue; passing the intensity data measurement through a first frequency band filter having a first bandwidth to produce a first output; passing the intensity data measurement through a second frequency band filter having a second bandwidth that is wider than the first bandwidth to produce a second output; determining, by a processor, an indication of fluid flow in the region of tissue by comparing the first output and the second output; and in response to determining a positive indication of fluid flow in the region of tissue, determining, by the processor, a blood analyte measurement based on at least some of the intensity data measurement. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. A method comprising:
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receiving, from an optical coherence tomography apparatus, an intensity data measurement for a region of tissue; passing the intensity data measurement through a first filter to produce a first output; passing the intensity data measurement through a second filter to produce a second output; analyzing, by a processor, fringe frequency data of the first output and the second output to determine an indication of fluid flow in the region of tissue; and in response to determining a positive indication of fluid flow in the region of tissue, analyzing, by the processor, the intensity data measurement to determine a blood analyte measurement. - View Dependent Claims (11, 12, 13, 14, 15, 16, 17, 18)
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Specification