Systems and methods to infer brain state during burst suppression

• US 10,383,574 B2
• Filed: 06/27/2014
• Issued: 08/20/2019
• Est. Priority Date: 06/28/2013
• Status: Active Grant

• Current Assignee: The General Hospital Corporation (Mass General Brigham, Inc.)
• Original Assignee: The General Hospital Corporation (Mass General Brigham, Inc.)
• Inventors: Purdon, Patrick L., Brown, Emery N., Lewis, Laura D., Westover, Brandon M., Ching, ShiNung
• Primary Examiner(s): Berhanu, Etsub D
• Application Number:
  US14/318,277
• Publication Number:
  US 20150011907A1
• Time in Patent Office: 1,880 Days
• Field of Search: None
• CPC Class Codes: A61B 5/291 for electroencephalography [EEG]
• CPC Class Codes: A61B 5/293 Invasive
• CPC Class Codes: A61B 5/4064 Evaluating the brain A61B5/031, A61B5/369, A61B5/14553 take precedence
• CPC Class Codes: A61B 5/4821 Determining level or depth of anaesthesia A61B5/1106 takes precedence
• CPC Class Codes: A61B 5/4839 combined with drug delivery
• CPC Class Codes: A61B 5/6814 Head

Abstract

Systems and methods are provided for monitoring a subject, and particularly, for inferring an underlying brain state present in absence of current conditions. In some aspects, a method for monitoring the subject is provided including steps of receiving physiological feedback from at least one sensor configured to acquire physiological information from locations associated with a subject'"'"'s brain, assembling a set of time-series data using the received physiological feedback, and identifying portions of the set of time-series data that indicate a burst suppression state. The method also includes identifying a burst characteristic profile associated with a burst pattern determined from the identified portions, and comparing the burst characteristic against a reference set of burst profiles. The method further includes determining, based on the comparison, a likelihood of a brain state of the subject underlying the burst suppression state, and generating a report indicative of the likelihood of the determined brain state.

Claims

1. A system for monitoring a subject, the system comprising:

a plurality of electroencephalogram (EEG) sensors configured to acquire EEG signals from multiple locations about a subject'"'"'s brain;

an input configured to receive at least the EEG signals from the plurality of EEG sensors;

a processor in communication with the input and configured to;

i) receive the EEG signals from the input;

ii) assemble a set of time-series data using the EEG signals received;

iii) analyze the set of time-series data to identify burst or burst suppression epochs corresponding to a burst suppression state;

iv) identify a burst characteristic profile for the subject based on a burst pattern determined from the epochs identified in (iii), wherein the burst pattern represents spatial and temporal occurrences of bursts across cortical regions of the subject'"'"'s brain;

v) compare the burst characteristic profile against a reference set of burst profiles; and

vi) determine, based on the comparison of (v), a likelihood of a brain state of the subject underlying the burst suppression state; and

a display configured to provide a report, generated by the processor, indicating the likelihood of the brain state determined in (vi).

2. The system of claim 1, wherein the processor is further configured to apply a segmentation algorithm to identify the epochs in the set of time-series data.

3. The system of claim 1, wherein the burst characteristic profile includes a burst spectral content.

4. The system of claim 1, wherein the processor is further configured to determine at least one of a burst timing pattern and a spatial pattern using the burst activity across the subject'"'"'s brain.

5. The system of claim 1, wherein the reference set of burst profiles is related to a non-burst suppression state.

6. The system of claim 1, wherein the processor is further configured to generate and provide an indication in relation to a future brain state of the subject upon recovery from the burst suppression state.

7. The system of claim 1, further comprising a controller for controlling a future brain state of the subject using the determined brain state.

8. The system of claim 1, wherein the display is further configured to indicate a burst cluster illustrative of concurrent burst activity across the subject'"'"'s brain.

9. A method for monitoring a subject comprising steps of:

(a) acquiring electroencephalogram (EEG) signals from multiple locations about a subject'"'"'s brain using a plurality of EEG sensors positioned thereabout; and

using a processor

(b) assembling a set of time-series data using the EEG signals acquired;

(c) analyzing the set of time-series data to identify burst or burst suppression epochs corresponding to a burst suppression state;

(d) identifying a burst characteristic profile for the subject based on a burst pattern determined from the epochs identified at step (c), wherein the burst pattern represents spatial and temporal occurrences of bursts across cortical regions of the subject'"'"'s brain;

(e) comparing the burst characteristic profile against a reference set of burst profiles;

(f) determining, based on the comparison of step (e), a likelihood of a brain state of the subject underlying the burst suppression state; and

(g) generating a report indicative of the likelihood of the brain state determined in step (f).

10. The method of claim 9, the method further comprising applying a segmentation algorithm to identify the epochs of the set of time-series data.

11. The method of claim 9, wherein the burst characteristic profile includes a burst spectral content.

12. The method of claim 9, the method further comprising determining at least one of a burst timing pattern and a spatial pattern using the burst activity across the subject'"'"'s brain.

13. The method of claim 9, wherein the reference set of burst profiles is related to a non-burst suppression state.

14. The method of claim 9, the method further comprising providing an indication in relation to a future state of the subject upon recovery from the burst suppression state.

15. The method of claim 9, the method further comprising indicating a burst cluster illustrative of concurrent burst activity across the a subject'"'"'s brain.

16. The method of claim 9, the method further comprising controlling a future brain state of the subject using the determined brain state.