Hyaluronic acid-based gels including lidocaine

  • US 10,391,202 B2
  • Filed: 11/09/2018
  • Issued: 08/27/2019
  • Est. Priority Date: 08/04/2008
  • Status: Active Grant
First Claim
Patent Images

1. A stable, sterile soft tissue filler comprising:

  • a hyaluronic acid (HA) component comprising HA crosslinked with 1,4-butanediol diglycidyl ether (BDDE), and uncrosslinked HA, wherein the HA component comprises greater than about 10% uncrosslinked HA by volume; and

    lidocaine at a concentration of about 0.3% by weight of the soft tissue filler combined with the HA component;

    wherein the stable, sterile soft tissue filler is made by a process comprising;

    providing the HA component;

    adjusting the pH of the HA component to an adjusted pH above about 7.2;

    adding a solution containing lidocaine to the HA component having the adjusted pH to obtain a soft tissue filler; and

    heat sterilizing the soft tissue filler to obtain a stable, sterile soft tissue filler.

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