Peptides enhancing neuronal outgrowth and application thereof

• US 10,407,465 B2
• Filed: 10/20/2015
• Issued: 09/10/2019
• Est. Priority Date: 10/20/2014
• Status: Active Grant

• Current Assignee: Schweitzer Biotech Company Ltd.
• Original Assignee: Schweitzer Biotech Company Ltd.
• Inventors: Yang, Ying-Chen
• Primary Examiner(s): Ballard, Kimberly
• Application Number:
  US15/520,605
• Publication Number:
  US 20170362274A1
• Time in Patent Office: 1,421 Days
• CPC Class Codes: A61K 38/00 Medicinal preparations containing peptides peptides containing beta-lactam rings A61K31/00; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, A61K31/00; ergot alkaloids of the cyclic peptide type A61K31/48; containing macromolecular compounds having statistically distributed amino acid units A61K31/74; medicinal preparations containing antigens or antibodies A61K39/00; medicinal preparations characterised by the non-active ingredients, e.g. peptides as drug carriers, A61K47/00
• CPC Class Codes: A61K 38/08 Peptides having 5 to 11 amino acids A61K38/043 - A61K38/046 take precedence
• CPC Class Codes: A61K 38/16 Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof enzyme inhibitors A61K38/005
• CPC Class Codes: A61P 25/00 Drugs for disorders of the nervous system
• CPC Class Codes: C07K 14/00 Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
• CPC Class Codes: C07K 7/06 having 5 to 11 amino acids
• CPC Class Codes: C12N 15/11 DNA or RNA fragments; Modified forms thereof DNA or RNA not used in recombinant technology, C07H21/00; Non-coding nucleic acids having a biological activity

Abstract

The present invention relates to peptides enhancing neuronal outgrowth, particularly to peptides that enhance neurite outgrowth and their application.

Claims

1. A peptide enhancing neuronal outgrowth, consisting of the following sequence:

Asn-X₁-X₂-Pro-Gln 

 

(SEQ ID NO;

     3),

wherein

X₁ is an amino acid selected from the group consisting of nonpolar amino acids; and

X₂ is an amino acid selected from the group consisting of naturally occurring amino acids and amino acid analogs;

wherein the peptide enhances neuronal outgrowth.

2. The peptide of claim 1, wherein the sequence is selected from the group consisting of NAIPQ (SEQ ID NO:

1), NPSPQ (SEQ ID NO;

     2), NFEPQ (SEQ ID NO;

     4), NMYPQ (SEQ ID NO;

     5), NIKPQ (SEQ ID NO;

     6), NLMPQ (SEQ ID NO;

     7), NVAPQ (SEQ ID NO;

     8), and NWLPQ (SEQ ID NO;

     9).

3. A composition, comprising a peptide of claim 1 and a pharmaceutically acceptable vehicle.

4. A method for enhancing neuronal outgrowth, comprising contacting a neuronal cell with a peptide of claim 1 in an amount sufficient to enhance neuronal outgrowth.

5. The method of claim 4, wherein the neuronal cell is normal or damaged.