Analyte sensor

• US 10,420,494 B2
• Filed: 01/23/2018
• Issued: 09/24/2019
• Est. Priority Date: 07/02/2009
• Status: Active Grant

• Current Assignee: DexCom Incorporated
• Original Assignee: DexCom Incorporated
• Inventors: Simpson, Peter C., Boock, Robert J., Kamath, Apurv Ullas, Wightlin, Matthew D., Estes, Michael J.
• Primary Examiner(s): Messersmith, Eric J
• Application Number:
  US15/877,682
• Publication Number:
  US 20180146896A1
• Time in Patent Office: 609 Days
• CPC Class Codes: A61B 2560/0223 of calibration, e.g. protocols for calibrating sensors
• CPC Class Codes: A61B 2562/0209 Special features of electrodes classified in A61B5/24, A61B5/25, A61B5/283, A61B5/291, A61B5/296, A61B5/053
• CPC Class Codes: A61B 2562/043 in a linear array
• CPC Class Codes: A61B 2562/125 characterised by the manufacture of electrodes
• CPC Class Codes: A61B 5/14503 invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors A61B5/1459, A61B5/1464, A61B5/1473, A61B5/1482, A61B5/14865 take precedence
• CPC Class Codes: A61B 5/1451 for interstitial fluid
• CPC Class Codes: A61B 5/14517 for sweat
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/1473 invasive, e.g. introduced into the body by a catheter A61B5/1482 takes precedence
• CPC Class Codes: A61B 5/14865 invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
• CPC Class Codes: B05C 3/02 the work being immersed in the liquid or other fluent material
• CPC Class Codes: B05C 3/10 the articles being moved through the liquid or other fluent material conveying articles through baths B65G, e.g. B65G49/02
• CPC Class Codes: B05C 3/125 the work being a web, band, strip or the like
• CPC Class Codes: B05C 5/0241 for applying liquid or other fluent material to elongated work, e.g. wires, cables, tubes
• CPC Class Codes: B05D 1/18 performed by dipping
• CPC Class Codes: B05D 3/06 by exposure to radiation B05D3/02 takes precedence ; plasma treatment B05D3/141
• CPC Class Codes: B23K 26/0823 Devices involving rotation of the workpiece
• CPC Class Codes: B23K 26/362 Laser etching
• CPC Class Codes: B29C 2791/009 Using laser curing using laser B29C2035/0838, welding using laser beams B29C65/16
• CPC Class Codes: C23C 2/00 : Hot-dipping or immersion processes for applying the coating material in the molten state without affecting the shape; Apparatus therefor

Abstract

Devices and methods are provided for continuous measurement of an analyte concentration. The device can include a sensor having a plurality of sensor elements, each having at least one characteristic that is different from other sensor(s) of the device. In some embodiments, the plurality of sensor elements are each tuned to measure a different range of analyte concentration, thereby providing the device with the capability of achieving a substantially consistent level of measurement accuracy across a physiologically relevant range. In other embodiments, the device includes a plurality of sensor elements each tuned to measure during different time periods after insertion or implantation, thereby providing the sensor with the capability to continuously and accurately measure analyte concentrations across a wide range of time periods. For example, a sensor system 180 is provided having a first working electrode 150 comprising a first sensor element 102 and a second working electrode 160 comprising a second sensor element 104, and a reference electrode 108 for providing a reference value for measuring the working electrode potential of the sensor elements 102, 104.

Claims

1. A sensor system for continuous measurement of a glucose concentration in a host, the sensor system comprising:

a first continuous glucose sensor configured to measure glucose concentrations over a first time period of in vivo implantation and produce first sensor data, wherein the first sensor is configured to have a run-in time between 0.1 and 6 hours;

a second continuous glucose sensor configured to measure glucose concentrations over a second time period of in vivo implantation and produce second sensor data, wherein the second continuous glucose sensor is an optical sensor, wherein the first time period and the second time period are different, wherein the second time period begins after the first time period begins, wherein the first time period and the second time period overlap partially, but not completely; and

sensor electronics configured to determine glucose concentration values based on the first sensor data and the second sensor data, wherein the sensor electronics are configured to determine the glucose concentration values by integrating signals from the first sensor data and signals from the second sensor data, wherein the sensor electronics are configured to integrate signals from the first sensor data and signals from the second sensor data by according first weights to signals from the first sensor data and according second weights to signals from the second sensor data, and wherein magnitudes of the first weight and magnitudes of the second weights are dependent on a time period of a sensor session.

2. The sensor system of claim 1, wherein the first time period corresponds to an initial period of in vivo implantation, wherein the second time period corresponds to a second time period of in vivo implantation, and wherein the second period begins after the initial period of in vivo implantation has begun.

3. The sensor system of claim 2, wherein the first time period begins before less than 3 hours post-implantation, and wherein the second time period begins after more than 3 hours post-implantation.

4. The sensor system of claim 2, wherein the first time period begins before less than 6 hours post-implantation, and wherein the second time period begins after more than 6 hours post-implantation.

5. The sensor system of claim 1, wherein the sensor system is configured for transcutaneous placement through a skin of a host.

6. The sensor system of claim 1, wherein the sensor system is configured for fluid communication with a vascular system of a host.

7. The sensor system of claim 1, wherein the first sensor is an optical sensor.

8. The sensor system of claim 1, wherein the second sensor is an electrochemical sensor.