Method and/or system for determining blood glucose reference sample times

• US 10,433,774 B2
• Filed: 09/16/2016
• Issued: 10/08/2019
• Est. Priority Date: 07/06/2010
• Status: Active Grant

• Current Assignee: Medtronic Minimed Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Minimed Incorporated (Medtronic Plc)
• Inventors: Gottlieb, Rebecca K., Ramachandran, Meena
• Primary Examiner(s): Bloch, Michael R
• Application Number:
  US15/268,063
• Publication Number:
  US 20170065212A1
• Time in Patent Office: 1,117 Days
• Field of Search: None
• CPC Class Codes: A61B 5/14503 invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors A61B5/1459, A61B5/1464, A61B5/1473, A61B5/1482, A61B5/14865 take precedence
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/4839 combined with drug delivery
• CPC Class Codes: A61B 5/6849 in combination with a needle set
• CPC Class Codes: A61B 5/7221 Determining signal validity, reliability or quality A61B5/7207 and A61B5/7217 take precedence
• CPC Class Codes: A61B 5/742 using visual displays A61B5/339 takes precedence
• CPC Class Codes: A61M 2005/14208 with a programmable infusion control system, characterised by the infusion program
• CPC Class Codes: A61M 2205/18 with alarm
• CPC Class Codes: A61M 2205/50 with microprocessors or computers
• CPC Class Codes: A61M 2230/201 Glucose concentration
• CPC Class Codes: A61M 5/14244 adapted to be carried by the patient, e.g. portable on the body
• CPC Class Codes: A61M 5/1723 using feedback of body parameters, e.g. blood-sugar, pressure measurement of body parameters A61B5/00

Abstract

Subject matter disclosed herein relates to monitoring and/or controlling blood glucose levels in patients. In particular, times for obtaining metered blood glucose samples of a patient may be altered based, at least in part, on a blood glucose level of said patient observed from a blood glucose sensor.

Claims

1. A method comprising:

obtaining from a patient a first blood glucose reference sample measurement while monitoring a blood glucose level in the patient by processing signals from a continuous blood glucose sensor;

determining an extension of a scheduled time for obtaining from the patient a second blood glucose reference sample measurement,

wherein the determining of the extension is performed by one or more processors and is based, at least in part, on a difference between the first blood glucose reference sample measurement and an upper bound of a target range blood glucose level being less than a first threshold, wherein the first blood glucose reference sample has a value greater than the upper bound,

wherein the determining of the extension is further based, at least in part, on a slope of an observed blood glucose level while the observed blood glucose level is above the target range blood glucose level, wherein the slope is decreasing, and wherein the observed blood glucose level is as observed from the continuous blood glucose sensor, and

wherein the determining of the extension is further based, at least in part, on a prediction that a blood glucose level in the patient is to be within the target range at a scheduled blood glucose reference sample time after the obtaining of the first blood glucose reference sample measurement; and

responsive to the determined extension, generating signals to provide a message to an operator or attendant indicating an option to extend the scheduled time for obtaining the second blood glucose reference sample measurement.

2. The method of claim 1, wherein the determining of the extension is further based, at least in part, on a variability of the observed blood glucose level being below a second threshold.

3. The method of claim 1, wherein the determining of the extension is further based, at least in part, on an observed change in an insulin sensitivity of the patient being below a second threshold.

4. The method of claim 1, wherein the first threshold is 50.0 mg/dl.

5. The method of claim 1, wherein the generating of the signals to provide the message comprises displaying the message to the operator or attendant indicating the option to extend the scheduled time for obtaining the second blood glucose reference sample measurement.

6. An apparatus for use by an operator or an attendant, for use with a continuous blood glucose sensor, and for use with a first blood glucose reference sample measurement taken from a patient, the apparatus comprising:

a controller configured to;

receive signals associated with a value of the first blood glucose reference sample measurement;

monitor a blood glucose level in the patient by processing signals from the continuous blood glucose sensor;

determine an extension of a scheduled time for obtaining from the patient a second blood glucose reference sample measurement based, at least in part, on a difference between the value of the first blood glucose reference sample measurement and an upper bound of a target range blood glucose level being less than a first threshold, wherein the value of the first blood glucose reference sample is greater than the upper bound,

wherein the determination of the extension is further based, at least in part, on a slope of an observed blood glucose level while the observed blood glucose level is above the target range blood glucose level, wherein the slope is decreasing, and wherein the observed blood glucose level is as observed from the continuous blood glucose sensor, and

wherein the determination of the extension is further based, at least in part, on a prediction that a blood glucose level in the patient is to be within the target range at a scheduled blood glucose reference sample time after the obtaining of the first blood glucose reference sample measurement; and

responsive to the determined extension, initiate a signal to provide a message to the operator or attendant indicating an option to extend the scheduled time for obtaining the second blood glucose reference sample measurement.

7. The apparatus of claim 6, wherein the controller is further configured to determine the extension based, at least in part, on a variability of the observed blood glucose level being below a second threshold.

8. The apparatus of claim 6, wherein the controller is further configured to determine the extension based, at least in part, on an observed change in an insulin sensitivity of the patient being below a second threshold.

9. The apparatus of claim 6, wherein the apparatus is further for use with a display, and wherein the controller is further configured to initiate the signal to provide the message to the operator or attendant by initiating the signal to display the message on the display to the operator or attendant.