Systems for the detection and delivery of neurochemical and electrical signals for functional restoration

• US 10,441,791 B2
• Filed: 06/29/2018
• Issued: 10/15/2019
• Est. Priority Date: 01/09/2013
• Status: Active Grant

• Current Assignee: Mayo Foundation For Medical Education And Research (Mayo Clinic)
• Original Assignee: Mayo Foundation For Medical Education And Research (Mayo Clinic)
• Inventors: Bennet, Kevin E., Lee, Kendall H.
• Primary Examiner(s): Bockelman, Mark
• Application Number:
  US16/023,964
• Publication Number:
  US 20190030340A1
• Time in Patent Office: 473 Days
• CPC Class Codes: A61N 1/0534 Electrodes for deep brain stimulation
• CPC Class Codes: A61N 1/0551 Spinal or peripheral nerve electrodes
• CPC Class Codes: A61N 1/36139 with automatic adjustment

Abstract

This document provides methods and materials involved in detecting and delivering neurochemical signals, electrophysiological signals, ions, or combinations thereof within a mammal. For example, systems that can include one or more implantable devices containing probes configured to detect neurochemical signals (e.g., neurotransmitter concentrations), electrical signals, ions, or combinations thereof and one or more implantable devices containing electrodes and/or microfluidic delivery components configured to deliver neurochemical signals (e.g., neurotransmitters), electrical signals, ions, or combinations thereof to one or more locations within a mammal are provided.

Claims

1. A method comprising:

detecting, using one or more probes of a first implantable device located within a first region of a brain of a mammal, first neurochemical signals that indicate concentrations of one or more neurotransmitters within said first region of said brain or first electrical signals that indicate electrical activity of said first region of said brain;

telemetering, from a first control unit of said first implantable device and to a second control unit of a second implantable device that is located proximal to a targeted nerve tissue downstream of a damaged or severed nerve tissue of said mammal outside of said brain of said mammal, first information about said first neurochemical signals or about said first electrical signals;

receiving, by said second control unit of said second implantable device, said first information about said first neurochemical signals or about said first electrical signals;

delivering, using one or more electrodes of said second implantable device, electrical stimulation to said targeted nerve tissue based on said first information about said first neurochemical signals;

detecting, using one or more probes of said second implantable device, second neurochemical signals that indicate concentrations of one or more neurotransmitters within a region proximal to said targeted nerve tissue or second electrical signals that indicate electrical activity of said region proximal to said targeted nerve tissue;

telemetering, from said second control unit of said second implantable device and to a third control unit of a third implantable device that is located within a second region of said brain of said mammal, second information about said second neurochemical signals or about said second electrical signals, wherein said second region is different from said first region of said brain of said mammal;

receiving, by said third control unit of said third implantable device, said second information about said second neurochemical signals or about said second electrical signals; and

delivering, using one or more electrodes or one or more microfluidic delivery components of said third implantable device, electrical stimulation or one or more neurochemicals to said second region of said brain of said mammal based on said second information about said second neurochemical signals or about said second electrical signals.

2. The method of claim 1, wherein:

said first information that is telemetered from said first control unit of said first implantable device comprises a first delivery signal profile, and said second information that is telemetered from said second control unit of said second implantable device comprises a second delivery signal profile; and

said second implantable device is configured to deliver electrical stimulation to said targeted nerve tissue according to said first delivery signal profile, and said third implantable device is configured to deliver electrical stimulation or neurochemicals to said second region of said brain according to said second delivery signal profile.

3. The method of claim 1, wherein:

telemetering said first information from said first control unit of said first implantable device to said second control unit of said second implantable device comprises transmitting said first information from said first control unit to said second control unit indirectly via a processing unit that is separate from each of said first control unit, said control unit, and said third control unit; and

telemetering said second information from said second control unit of said second implantable device to said third control unit of said third implantable device comprises transmitting said second information from said second control unit to said third control unit indirectly via said processing unit.

4. The method of claim 3, wherein said processing unit is configured to:

determine a first delivery signal profile based on said first information from said first implantable device, and to telemeter said first delivery signal profile to said second implantable device; and

determine a second delivery signal profile based on said second information from said second implantable device, and to telemeter said second delivery signal profile to said second implantable device.

5. The method of claim 1, wherein said second implantable device is configured to be located within a limb, a diaphragm, a genital region, a bladder, a vascular system, or facial tissue of said mammal.

6. The method of claim 1, wherein said second implantable device is configured to be located in a spinal cord region of said mammal.

7. The method of claim 1, wherein communication of biological signals between said brain of said mammal and said targeted nerve tissue is impaired as a result of said damaged or severed nerve tissue, wherein said system is arranged to at least partially restore communication between said brain of said mammal and said targeted nerve tissue.

8. The method of claim 1, wherein said first implantable device comprises a sensor that is configured to detect different ones of multiple neurochemicals within said first region of said brain by applying electrical signals with different voltage ramps within said first region of said brain.

9. The method of claim 1, wherein delivering one or more neurochemicals to said second region of said brain of said mammal comprises administering at least one of adenosine, serotonin, or norepinephrine to said second region of said brain.

10. The method of claim 1, comprising detecting, using said one or more probes of said first implantable device, said first neurochemical signals that indicate concentrations of said one or more neurotransmitters within said first region of said brain of said mammal.

11. The method of claim 1, comprising detecting, using said one or more probes of said first implantable device, said first electrical signals that indicate electrical activity of said first region of said brain.

12. The method of claim 1, comprising delivering, using said one or more electrodes of said third implantable device, electrical stimulation to said second region of said brain of said mammal based on said second information.

13. The method of claim 1, comprising delivering, using said one or more microfluidic delivery components of said third implantable device, said one or more neurochemicals to said second region of said brain of said mammal based on said second information.

14. A system comprising:

a first implantable device comprising (i) a first control unit configured to provide wireless communication capabilities for said first implantable device and (ii) a first probe configured to detect, within a first region of a brain of a mammal, at least one of electrical signals within said first region of said brain or neurochemical signals that indicate concentrations of one or more neurotransmitters within said first region of said brain;

a second implantable device comprising (i) a second control unit configured to provide wireless communication capabilities for said second implantable device, (ii) a first electrode configured to deliver electrical stimulation to targeted nerve tissue that is located outside of said brain and downstream of damaged or severed nerve tissue of said mammal and (iii) a second probe configured to detect neurochemical signals that indicate concentrations of one or more neurotransmitters within a region proximal to said targeted nerve tissue; and

a third implantable device comprising (i) a third control unit configured to provide wireless communication capabilities for said third implantable device and (ii) a second electrode configured to deliver electrical signals to a second region of said brain that is different from said first region of said brain or a microfluidic delivery component configured to administer a neurochemical to said second region of said brain;

wherein said first implantable device is configured to use said first control unit to wirelessly telemeter first information about said electrical signals or said neurochemical signals detected by said first probe of said first implantable device within said first region of said brain,

wherein said second implantable device is configured to receive with said second control unit said first information that was wirelessly telemetered from said first implantable device, or to receive information derived from said first information, and to deliver electrical stimulation to said targeted nerve tissue outside of said brain based on said first information, or based on said information derived from said first information,

wherein said second implantable device is configured to use said second control unit to wirelessly telemeter second information about said neurochemical signals detected by said second implantable device within said region proximal to said targeted nerve tissue outside of said brain, and

wherein said third implantable device is configured to receive with said third control unit said second information that was wirelessly telemetered from said second implantable device, or to receive information derived from said second information, and to deliver electrical stimulation or administer neurochemicals to said second region of said brain based on said second information, or based on said information derived from said second information, about said neurochemical signals detected by said second implantable device within said region proximal to said targeted nerve tissue outside of said brain.

15. The system of claim 14, wherein said probe of said first implantable device is configured to detect, within said first region of said brain of said mammal, electrical signals within said first region of said brain of said mammal that indicate electrical activity of said brain within said first region.

16. The system of claim 14, wherein said probe of said first implantable device is configured to detect, within said first region of said brain of said mammal, neurochemical signals that indicate concentrations of one or more neurotransmitters within said first region of said brain.

17. The system of claim 14, further comprising a processing unit that is separate from each of said first implantable device, said second implantable device, and said third implantable device, wherein said processing unit is configured to:

receive said first information that was telemetered from said first implantable device, determine a first delivery signal profile based on said first information, and to telemeter said first delivery signal profile to said second implantable device as said information derived from said first information to cause said second implantable device to deliver electrical stimulation to said targeted nerve tissue according to said first delivery signal profile.

18. The system of claim 17, wherein said processing unit is further configured to receive said second information that was telemetered from said second implantable device, determine a second delivery signal profile based on said second information, and to telemeter said second delivery signal profile to said third implantable device as said information derived from said second information to cause said third implantable device to deliver electrical stimulation or administer neurochemicals to said second region of said brain of said mammal according to said second delivery signal profile.