Anti-sclerostin antibody, antigen binding fragment and medical use thereof

  • US 10,449,250 B2
  • Filed: 02/16/2016
  • Issued: 10/22/2019
  • Est. Priority Date: 03/13/2015
  • Status: Active Grant
First Claim
Patent Images

1. An antibody or antigen-binding fragment thereof that specifically binds to human sclerostin, comprising:

  • (I) a heavy chain variable region comprising a heavy chain complementarity determining region 1 (CDR1), a heavy chain CDR2, and a heavy chain CDR3 having the amino acid sequences of SEQ ID NO;

    7, SEQ ID NO;

    8, and SEQ ID NO;

    9, respectively; and

    a light chain variable region comprising a light chain CDR1, a light chain CDR2, and a light chain CDR3 having the amino acid sequences of SEQ ID NO;

    10, SEQ ID NO;

    11, and SEQ ID NO;

    12, respectively;

    or(II) a heavy chain variable region comprising a heavy chain CDR1, a heavy chain CDR2, and a heavy chain CDR3 having the amino acid sequences of SEQ ID NO;

    7, SEQ ID NO;

    13, and SEQ ID NO;

    9, respectively; and

    a light chain variable region comprising a light chain CDR1, a light chain CDR2, and a light chain CDR3 having the amino acid sequences of SEQ ID NO;

    10, SEQ ID NO;

    11, and SEQ ID NO;

    12, respectively.

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