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Methods and apparatus for measuring analytes

  • US 10,451,585 B2
  • Filed: 10/29/2015
  • Issued: 10/22/2019
  • Est. Priority Date: 05/29/2009
  • Status: Active Grant
First Claim
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1. A method comprising:

  • measuring a waveform associated with a chemical event occurring on a sensor array, wherein the waveform comprises at least one region associated with expected measured values and at least one region associated with unpredictable measured values;

    applying a first frame averaging to the at least one region associated with the expected measured values, wherein the first frame averaging comprises averaging a first number of frames during the at least one region associated with the expected measured values to form first frame-averaged data, wherein the first frame-averaged data have a reduced amount of data for the region associated with the expected measured values;

    applying a second frame averaging to the at least one region associated with the unpredictable measured values, wherein the second frame averaging comprises averaging a second number of frames during the at least one region associated with the unpredictable measured values, the second number of frames being lower than the first number of frames, to form second frame-averaged data, wherein the second frame-averaged data have a reduced amount of data for the region associated with the unpredictable measured values;

    applying a third frame averaging to a second region of the waveform, wherein the second region is associated with another portion of the waveform with expected measured values, and wherein the third frame averaging comprises averaging a third number of frames during the second region, the third number of frames being higher than the second number of frames, wherein the third frame averaging forms third frame-averaged data, wherein the third frame-averaged data have a reduced amount of data for the second region associated with another portion of the waveform with expected measured values; and

    applying a keyframe delta compression to the frame-averaged data resulting from the first, second, and third frame averaging, wherein the keyframe delta compression comprises;

    storing in a memory an initial value for each pixel in a keyframe of the frame-averaged data,calculating a difference between a value for each pixel of a second frame of the frame-averaged data and a corresponding initial value for each pixel of the keyframe to form difference values, andstoring in the memory the difference values between the keyframe and the second frame, wherein the keyframe of frame-averaged data and the difference values provide compressed data associated with the waveform for storing in the memory.

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