Garment system including at least one therapeutic stimulation delivery device and related methods

• US 10,456,604 B2
• Filed: 02/16/2017
• Issued: 10/29/2019
• Est. Priority Date: 08/26/2014
• Status: Active Grant

• Current Assignee: Ventrk LLC
• Original Assignee: Elwha LLC (Intellectual Ventures LLC)
• Inventors: Cheatham, III, Jesse R., Hyde, Roderick A., Ishikawa, Muriel Y., Kare, Jordin T., Leuthardt, Eric C., Mankin, Max N., Myhrvold, Nathan P., Pan, Tony S., Petroski, Robert C., Sweeney, Elizabeth A., Tegreene, Clarence T., Touran, Nicholas W., Urzhumov, Yaroslav A., Whitmer, Charles, Wood, Jr., Lowell L., Wood, Victoria Y. H.
• Primary Examiner(s): Douglas, Steven O
• Application Number:
  US15/434,474
• Publication Number:
  US 20170157431A1
• Time in Patent Office: 985 Days
• CPC Class Codes: A61B 2090/064 for measuring force, pressure or mechanical tension
• CPC Class Codes: A61F 2007/0096 with a thermometer
• CPC Class Codes: A61F 2007/0233 connected to or incorporated in clothing or garments A61F2007/023 takes precedence
• CPC Class Codes: A61F 7/02 Compresses or poultices for effecting heating or cooling
• CPC Class Codes: A61H 2011/005 with belt or strap expanding and contracting around an encircled body part
• CPC Class Codes: A61H 2201/10 with further special therapeutic means, e.g. electrotherapy, magneto therapy or radiation therapy, chromo therapy, infrared or ultraviolet therapy
• CPC Class Codes: A61H 2201/1207 with electric or magnetic drive
• CPC Class Codes: A61H 2201/1604 Head
• CPC Class Codes: A61H 2201/1609 Neck
• CPC Class Codes: A61H 2201/1619 Thorax
• CPC Class Codes: A61H 2201/1623 Back
• CPC Class Codes: A61H 2201/1635 Hand or arm, e.g. handle hand-held, A61H2201/0153; fore-arm support, A61H2003/006
• CPC Class Codes: A61H 2201/164 Feet or leg, e.g. pedal
• CPC Class Codes: A61H 2201/165 Wearable interfaces
• CPC Class Codes: A61H 2201/5002 Means for controlling a set of similar massage devices acting in sequence at different locations on a patient
• CPC Class Codes: A61H 2201/5007 computer controlled
• CPC Class Codes: A61H 2201/5058 Sensors or detectors
• CPC Class Codes: A61H 2201/5082 Temperature sensors
• CPC Class Codes: A61H 2201/5092 Optical sensor
• CPC Class Codes: A61H 2201/5097 wireless
• CPC Class Codes: A61H 2230/207 : partial O2-value
• CPC Class Codes: A61H 2230/25 : Blood flowrate, e.g. by Doppler effect
• CPC Class Codes: A61H 2230/50 : Temperature
• CPC Class Codes: A61H 2230/60 : Muscle strain, i.e. measured on the user, e.g. Electromyography [EMG]
• CPC Class Codes: A61H 2230/65 : Impedance, e.g. skin conductivity; capacitance, e.g. galvanic skin response [GSR]
• CPC Class Codes: A61M 2230/005 : Parameter used as control input for the apparatus
• CPC Class Codes: A61M 2230/208 : pH-value
• CPC Class Codes: A61M 2230/50 : Temperature
• CPC Class Codes: A61M 2230/63 : Motion, e.g. physical activity
• CPC Class Codes: A61M 5/1723 : using feedback of body parameters, e.g. blood-sugar, pressure measurement of body parameters A61B5/00
• CPC Class Codes: A61N 1/0476 : Array electrodes (including any electrode arrangement with more than one electrode for at least one of the polarities)
• CPC Class Codes: A61N 1/0484 : Garment electrodes worn by the patient
• CPC Class Codes: A61N 1/36021 : for treatment of pain
• CPC Class Codes: A61N 2/002 : in combination with another treatment
• CPC Class Codes: A61N 2/008 : for pain treatment or analgesia
• CPC Class Codes: A61N 2005/0626 : Monitoring, verifying, controlling systems and methods
• CPC Class Codes: A61N 2005/0645 : Applicators worn by the patient
• CPC Class Codes: A61N 2007/0021 : Neural system treatment
• CPC Class Codes: A61N 2007/0073 : using multiple frequencies
• CPC Class Codes: A61N 2007/0078 : with multiple treatment transducers
• CPC Class Codes: A61N 5/04 : Radiators for near-field treatment
• CPC Class Codes: A61N 5/06 : using light
• CPC Class Codes: A61N 7/00 : Ultrasound therapy lithotripsy A61B17/22, A61B17/225; massage using supersonic vibration A61H23/00 ; using ultrasound for introducing media into the body A61M37/0092

Abstract

Embodiments disclosed herein relate to a garment system including a flexible compression garment, at least one sensor, and at least one therapeutic stimulation delivery device operable responsive to sensing feedback from the at least one sensor, effective to provide therapeutic radiation to a body part of a subject. Embodiments disclosed herein also relate to methods of using such garment systems.

Claims

1. A system for delivering therapeutic stimulation to a subject, the system comprising:

at least one flexible compression garment configured to be worn on at least one body part of the subject, the at least one flexible compression garment defining an interior space configured to receive the at least one body part;

one or more sensors positioned and configured to sense at least one characteristic of the at least one body part that is related to at least one of movement or a physiological state of the at least one body part, the one or more sensors further configured to output one or more sensing signals indicative of the at least one characteristic;

an array of therapeutic stimulation delivery devices (“

TSDDs”

) positioned and configured to dynamically apply therapeutic radiation to the at least one body part;

a controller operably coupled to the one or more sensors to receive the one or more sensing signals therefrom and to the array of TSDDs, the controller including control electrical circuitry configured to direct the array of TSDDs to dynamically apply the therapeutic radiation to a region of the at least one body part responsive to one or more sensing signals.

2. The system of claim 1, wherein the at least one flexible compression garment is formed at least partially from at least one of neoprene, nylon, synthetic rubber, or fabric.

3. The system of claim 1, wherein the at least one flexible compression garment includes a portion that is substantially tubular and configured to generally conform to the at least one body part, wherein the at least one body part includes at least a portion of an arm, at least a portion of an elbow, at least a portion of a forearm, at least a portion of a wrist, at least a portion of a hand, at least a portion of a finger, at least a portion of a thigh, at least a portion of a knee, at least a portion of a lower leg, at least a portion of a foot, at least a portion of a toe, at least a portion of a neck, at least a portion of a head, at least a portion of a back, at least a portion of a spine, or at least a portion of a chest.

4. The system of claim 1, wherein the at least one characteristic of the at least one body part that is related to at least one of movement or a physiological state of the at least one body part includes at least one of nerve activity of at least one tissue in the region, an internal temperature of the region, an external temperature, blood flow in the region, tissue oxygenation in the region, a strain on the at least one body part, a conductance in the region, an impedance in the region, a pH in a body fluid in the region, a chemical composition of a physiological analyte in the region, an acoustic emission from tissue in the region, biochemical activity in the region, changes of any of the foregoing exceeding a threshold value, or cessation of any of the foregoing for a duration longer than a selected duration of time.

5. The system of claim 1, wherein the at least one characteristic of the at least one body part that is related to at least one of movement or a physiological state of the at least one body part includes one or more of motion of the subject, motion of one or more limbs of the subject, a stationary condition of the subject, or a stationary condition of one or more limbs of the subject.

6. The system of claim 1, wherein the one or more sensors are configured to sense characteristics indicative of onset of muscle activity, muscular fatigue, conclusion of muscle activity, a threshold level of muscle activity in the region, or pain, and wherein the control electrical circuitry is configured to direct the at least one of the array of TSDDs to selectively initiate, terminate, or alter application of the therapeutic radiation to the at least one body part.

7. The system of claim 1, wherein the one or more sensors include at least one of an electrophysiological sensor, a myography sensor, a thermal sensor, a blood flow sensor, an oxygenation sensor, a chemical sensor, a motion sensor, a strain sensor, an electrode, a bioimpedance sensor, a pH sensor, or an acoustic sensor.

8. The system of claim 7, wherein the acoustic sensor is configured to stimulate the region of the at least one body part with acoustic radiation and receive reflected acoustic radiation responsive thereto.

9. The system of claim 8, wherein each of the acoustic radiation and the reflected acoustic radiation includes ultrasonic radiation.

10. The system of claim 1, wherein the array of TSDDs includes an array of ultrasound transducers each of which is configured to apply therapeutic ultrasonic radiation to the at least one body part.

11. The system of claim 10, wherein each ultrasound transducer of the of the array of ultrasound transducers is configured to apply the therapeutic ultrasonic radiation to the at least one body part effective to control a temperature of at least a region of the at least one body part, block one or more nerve signals, administer a medicament, or activate a medicament.

12. The system of claim 10, wherein each ultrasound transducer of the of the array of ultrasound transducers is configured to apply the therapeutic ultrasonic radiation to a common region in the at least one body part effective to control a temperature of the common region, collectively block one or more nerve signals, administer a medicament, or activate a medicament.

13. The system of claim 10, wherein at least one ultrasound transducer of the array of ultrasound transducers is configured to emit low frequency ultrasonic radiation.

14. The system of claim 10, wherein at least one ultrasound transducer of the array of ultrasound transducers is configured to emit high intensity ultrasonic radiation.

15. The system of claim 10, wherein the array of ultrasound transducers are configured to emit a plurality of pulses of acoustic radiation.

16. The system of claim 10, wherein the array of ultrasound transducers are configured to continuously emit acoustic radiation.

17. The system of claim 10, wherein the array of ultrasound transducers are configured to emit a plurality of frequencies of acoustic radiation.

18. The system of claim 10, wherein at least one ultrasound transducer of the array of ultrasound transducers is configured to emit a wavelength, a frequency, or an intensity of the therapeutic ultrasonic radiation effective to alter or maintain a temperature of a portion of the at least one body part.

19. The system of claim 10, wherein at least one ultrasound transducer of the array of ultrasound transducers is configured to emit the therapeutic ultrasonic radiation to a first region of the at least one body part and at least another ultrasound transducer of the array of ultrasound transducers is configured to emit therapeutic ultrasonic radiation to a second region of the at least one body part.

20. The system of claim 10, wherein at least one ultrasound transducer of the array of ultrasound transducers is configured to emit a first therapeutic ultrasonic radiation having one or more of a first wavelength, a first frequency, or a first intensity, and at least another ultrasound transducer of the array of ultrasound transducers is configured to emit one or more of at least a second therapeutic ultrasonic radiation having at least a second wavelength, at least a second frequency, or at least a second intensity differing from one or more of the first wavelength, the first frequency, or the first intensity.

21. The system of claim 20, wherein the first frequency is selected so that the first therapeutic ultrasonic radiation penetrates to a first depth in the at least one body part and the at least a second frequency is selected so that the at least a second therapeutic ultrasonic radiation penetrates to a second depth in the at least one body part, wherein the first depth and the second depth are different.

22. The system of claim 10, wherein at least one ultrasound transducer of the array of ultrasound transducers is configured to selectively emit one or more wavelengths, frequencies, or intensities of the therapeutic ultrasonic radiation.

23. The system of claim 22, wherein the at least one ultrasound transducer of the array of ultrasound transducers configured to selectively emit one or more wavelengths, frequencies, or intensities of the therapeutic ultrasonic radiation is configured to adjustably increase or decrease the one or more wavelengths, frequencies, or intensities during application of the therapeutic radiation to the at least one region responsive to one or more actuation signals.

24. The system of claim 10, wherein the at least one ultrasound transducer of the array of ultrasound transducers is configured to emit a wavelength, a frequency, or an intensity of the therapeutic ultrasonic radiation effective to alter or maintain a temperature of a portion of the at least one body part.

25. The system of claim 10, wherein the array of TSDDs includes one or more of at least one electrode, at least one magnetic field generator, at least one optical stimulator, at least one thermal control device, or at least one microwave emitter.

26. The system of claim 10, wherein at least one ultrasound transducer of the array of ultrasound transducers is selectively steerable to be aimed to one or more portions of the at least one body part responsive to aiming instructions delivered from the controller, wherein the aiming instructions are configured to direct the at least one ultrasound transducer to aim therapeutic ultrasonic radiation to a region in which the one or more sensors provide data that the controller determines indicates an activation condition is present.

27. The system of claim 26, wherein the at least one ultrasound transducer of the array of ultrasound transducers that is steerable includes a multi-element array wherein at least some elements of the multi-element array are oriented in selected focal points and are individually and selectively controllable to deliver the therapeutic ultrasonic radiation to the selected focal points.

28. The system of claim 26, wherein the at least one of the array of ultrasound transducers that are steerable include a mechanically steerable ultrasound transducer including a mechanically steerable base that is individually and selectively controllable to aim the mechanically steerable ultrasound transducer at a selected focal point effective to deliver the therapeutic ultrasonic radiation to the selected focal point.

29. The system of claim 26, wherein the one or more sensors include at least one sensing ultrasound transducer configured to emit sensing ultrasonic radiation to the region, wherein the controller is configured to direct the array of ultrasound transducers to aim at a specific portion of the region responsive to sensor information detected by the at least one sensing ultrasound transducer.

30. The system of claim 26, wherein:

at least one ultrasound transducer of the array of ultrasound transducers is steerable responsive to aiming instructions delivered from the controller;

the one or more sensors include a plurality of sensing ultrasound transducers each configured to emit sensing ultrasonic radiation; and

wherein the controller is configured to independently direct the at least one ultrasound transducer of the array of ultrasound transducers to aim the therapeutic ultrasonic radiation emitted therefrom to a first region of the at least one body part and at least another ultrasound transducer of the array of ultrasound transducers to aim the therapeutic ultrasonic radiation therefrom to at least a second region of the at least one body part, responsive to sensor information detected by the plurality of sensing ultrasound transducers.

31. The system of claim 30, wherein:

the plurality of sensing transducers are configured to scan the at least one body part including first and second regions with sensing ultrasound radiation during application of the therapeutic ultrasonic radiation to detect the at least one characteristic associated with movement or the at least one characteristic of a region the at least one body part including at least one of nerve activity of at least tissue in the at least one body part, an internal temperature of the at least one body part, an external temperature, blood flow in the at least one body part, tissue oxygenation in the at least one body part, strain on the at least one body part, conductance in the at least one body part, impedance in the at least one body part, pH in a body fluid in the at least one body part, chemical composition of a body fluid in the at least one body part, acoustic emission from tissue in the at least one body part, biochemical activity, temperature of at least one joint in the at least one body part, oxygenation of at least one joint in the at least one body part, acoustic emission from at least one joint in the at least one body part, biochemical activity of at least one joint in the at least one body part, or absence of any of the foregoing;

the controller is configured to determine if a threshold value has been reached for the at least one characteristic associated with movement or at least one characteristic of a region the at least one body part, or if a duration has been reached, and responsive thereto, send one or more aiming instructions to the at least one of the array of ultrasound transducers to aim the at least one ultrasound transducer of the array of ultrasound transducers to a different region, or send one or more actuation signals effective to terminate application of the therapeutic ultrasonic radiation or alter one or more of wavelength, frequency, or intensity of the therapeutic ultrasonic radiation.

32. The system of claim 1, further including one or more of at least one electrode, at least one magnetic field generator, at least one optical stimulator, at least one thermal control device, or at least one microwave emitter, each configured to emit radiation into the at least one body part.

33. The system of claim 1, wherein:

the one or more sensors includes at least one sensing ultrasound transducer configured to apply sensing ultrasonic radiation to tissue of the at least one body part and receive reflected sensing ultrasonic radiation responsive thereto; and

the at least one sensing ultrasound transducer includes an array of therapeutic ultrasound transducers configured to apply therapeutic ultrasonic radiation to the at least one body part.

34. The system of claim 33, wherein each of the at least one sensing ultrasound transducer and at least one of the array of therapeutic ultrasound transducers is a multipurpose ultrasound transducer configured to selectively emit both sensing ultrasonic radiation and therapeutic ultrasonic radiation.

35. The system of claim 33, wherein the controller is configured to selectively direct the array of therapeutic ultrasound transducers to initiate, terminate, or alter application of the therapeutic ultrasonic radiation to the region responsive to a determination of a presence or absence of the activation condition only if the sensed information indicates that the subject is moving in a specific pattern indicative of a specific activity, after an elapsed time of the specific activity of the subject, or after an elapsed time since termination of the specific activity of the subject.

36. The system of claim 33, wherein the controller is configured to receive the sensed information and determine a presence of an indication of pain.

37. The system of claim 36, wherein the controller is further configured to direct the array of therapeutic ultrasound transducers to deliver the therapeutic ultrasonic radiation responsive to a determination that that an indication of pain is present.

38. The system of claim 36, wherein the controller is configured to determine the presence of an indication of pain based on one or more of nerve signals indicative of pain, an amount of one or more chemicals in a fluid of the subject, or a specific pattern of movement.

39. The system of claim 38, wherein the one or more sensors include one or more chemical sensors, and the controller is configured to determine if a chemical indication of pain is present based at least in part on a detected presence or change in concentration of one or more analytes.

40. The system of claim 39, wherein the one or chemical sensors include one or more of a transdermal sensor, a reverse iontophoresis sensor, ion-selective electrodes, or an electrochemical sensor.

41. The system of claim 40, wherein the one or more analytes include one or more of a sugar, a salt, a lactate, an electrolyte, a hormone, a neuropeptide, a peptide, a protein, a nucleotide, derivatives of any of the foregoing, or oxygen.

42. The system of claim 1, further including at least one medicament delivery device operably coupled to the controller and configured to provide topical, transdermal, or intramuscular medicament delivery to the at least one body part.

43. The system of claim 42, wherein the controller is configured to cause the at least one medicament delivery device to selectively deliver the at least one medicament responsive to one or more sensing signals indicative of the at least one characteristic.

44. The system of claim 42, wherein the controller is configured to cause the at least one medicament delivery device to selectively deliver the at least one medicament, responsive to an elapsed duration or time of day.

45. The system of claim 44, wherein:

the at least one medicament includes a medicament that is altered responsive to exposure to ultrasonic radiation; and

the at least one medicament device includes an ultrasound transducer configured to provide ultrasonic radiation effective to the medicament to alter one or more of chemical composition, viscosity, or encapsulation of the at least one medicament.

46. The system of claim 1, further including a power supply operably coupled to the array of TSDDs and the control electrical circuitry.

47. The system of claim 1, wherein the controller includes a timer configured to inform the controller of a time of day or a duration of one or more of an elapsed time since an activity has commenced, an elapsed time since an activity as terminated, an elapsed time since application of the therapeutic ultrasonic radiation has commenced, an elapsed time since application of the therapeutic ultrasonic radiation in a specific region of the at least one body part has commenced, or an elapsed time since application of the therapeutic ultrasonic radiation has terminated.

48. The system of claim 47, wherein:

the array of TSDDs includes an array of ultrasound transducers configured to emit therapeutic ultrasonic radiation; and

the controller is configured to selectively direct the array of ultrasound transducers to initiate, terminate, or alter application of the therapeutic ultrasonic radiation to the at least one body part responsive to the time of day or the duration indicated by the clock.

49. A garment system for delivering therapeutic stimulation to a subject, the garment system comprising:

at least one flexible compression garment configured to be worn on at least one body part of the subject;

one or more sensors positioned and configured to sense at least one characteristic of the at least one body part that is related to at least one of movement or a physiological state of the at least one body part, the one or more sensors further configured to output one or more sensing signals indicative of the at least one characteristic;

an array of steerable ultrasound transducers positioned and configured to selectively apply therapeutic ultrasonic radiation to one or more selected regions of the at least one body part;

a controller operably coupled to the one or more sensors to receive the one or more sensing signals therefrom and the array of steerable ultrasound transducers, the controller including;

processing electrical circuitry configured to direct the array of steerable ultrasound transducers to selectively aim and emit radiation to the one or more selected regions of the at least one body part responsive to one or more sensing signals; and

a memory storage medium operably coupled to the processing electrical circuitry, the memory storage medium having one or more machine readable programs stored therein, wherein the processing electrical circuitry is configured to execute the one or more machine readable programs; and

a power supply operably coupled to the controller, the one or more sensors, and the array steerable of ultrasound transducers.