Stable crystal form of tipiracil hydrochloride and crystallization method for the same

  • US 10,457,666 B2
  • Filed: 05/02/2018
  • Issued: 10/29/2019
  • Est. Priority Date: 06/17/2013
  • Status: Active Grant
First Claim
Patent Images

1. Crystal Form I of 5-chloro-6-(2-iminopyrrolidin-1-yl)methyl-2,4(1H,3H)-pyrimidinedione hydrochloride exhibiting powder X-ray peaks at two or more angles selected from the group consisting of 11.6°

  • , 17.2°

    , 17.8°

    , 23.3°

    , 27.1°

    , and 29.3°

    as a diffraction angle (2θ

    ±

    0.2°

    ), and having a purity of at least 90% by mass.

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