Factor IX polypeptide mutant, its uses and method for its production

  • US 10,465,180 B2
  • Filed: 05/25/2018
  • Issued: 11/05/2019
  • Est. Priority Date: 09/15/2008
  • Status: Active Grant
First Claim
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1. An adeno-associated virus vector comprising:

  • a. a nucleic acid encoding a modified FIX polypeptide, the modified FIX polypeptide comprising at least 70% identity to SEQ ID NO;

    2 and a leucine in position 338 of SEQ ID NO;

    2; and

    b. promoter sequences, transcription termination, and control elements.

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