Microorganism producing O-acetyl homoserine and the method of producing O-acetyl homoserine using the same
First Claim
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1. A microorganism of Escherichia sp. producing O-acetyl homoserine, wherein the endogenous activity of citrate synthase is attenuated or inactivated, and a homoserine O-acetyltransferase is further introduced or enhanced, or an endogenous homoserine O-succinyltransferase is further modified to a polypeptide having 95% identity or above with SEQ ID NO:
- 16 and further having mutations at the G111E position and L112T or L112H positions to have the activity of homoserine O-acetyltransferase, wherein the microorganism has an improved O-acetyl homoserine production capability compared to a corresponding unmodified Escherichia sp. microorganism.
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Abstract
Disclosed is a microorganism of Escherichia sp. producing O-acetyl homoserine, and a method of producing O-acetyl homoserine in high yield using the microorganism.
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6 Claims
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1. A microorganism of Escherichia sp. producing O-acetyl homoserine, wherein the endogenous activity of citrate synthase is attenuated or inactivated, and a homoserine O-acetyltransferase is further introduced or enhanced, or an endogenous homoserine O-succinyltransferase is further modified to a polypeptide having 95% identity or above with SEQ ID NO:
- 16 and further having mutations at the G111E position and L112T or L112H positions to have the activity of homoserine O-acetyltransferase, wherein the microorganism has an improved O-acetyl homoserine production capability compared to a corresponding unmodified Escherichia sp. microorganism.
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