Solid nanoparticle with inorganic coating

  • US 10,478,402 B2
  • Filed: 07/10/2017
  • Issued: 11/19/2019
  • Est. Priority Date: 05/24/2013
  • Status: Active Grant
First Claim
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1. A method of preparing a controlled or delayed release pharmaceutical composition comprising:

  • i. a plurality of coated particles of a size that is from 0.1 μ

    m to 50 μ

    m, said coated particles having a solid core comprising a biologically active substance, said solid core being enclosed by one or more metal oxide materials; and

    ii. a pharmaceutically acceptable carrier,the method comprising the sequential steps of;

    (1) applying an initial coating of at least one metal oxide to said solid cores in an atomic layer deposition reactor;

    (2) discharging the coated particles from the reactor and subjecting the coated particles to agitation to disaggregate particle aggregates formed during step (1);

    (3) reintroducing the disaggregated, coated particles from step (2) into an atomic layer deposition reactor and applying a further coating of at least one metal oxide to the reintroduced particles;

    (4) optionally repeating steps (2) and (3) one or more times to increase total thickness of the one or more metal oxide materials that enclose said solid core; and

    (5) admixing said coated particles obtained from step (3) or step (4) with said pharmaceutically acceptable carrier to form said pharmaceutical composition.

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