Devices for integrated indirect sweat stimulation and sensing

• US 10,485,460 B2
• Filed: 02/12/2016
• Issued: 11/26/2019
• Est. Priority Date: 02/13/2015
• Status: Active Grant

• Current Assignee: University of Cincinnati
• Original Assignee: University of Cincinnati
• Inventors: Sonner, Zachary Cole, Heikenfeld, Jason C.
• Primary Examiner(s): Agahi, Puya
• Application Number:
  US15/544,725
• Publication Number:
  US 20180035928A1
• Time in Patent Office: 1,383 Days
• CPC Class Codes: A61B 10/0064 for taking sweat or sebum samples measuring sweat production A61B5/4266
• CPC Class Codes: A61B 2560/0412 Low-profile patch shaped housings
• CPC Class Codes: A61B 2562/166 the sensor is mounted on a specially adapted printed circuit board
• CPC Class Codes: A61B 5/053 Measuring electrical impedance or conductance of a portion of the body
• CPC Class Codes: A61B 5/0533 Measuring galvanic skin response
• CPC Class Codes: A61B 5/14507 specially adapted for measuring characteristics of body fluids other than blood devices for taking samples of body liquids A61B10/0045
• CPC Class Codes: A61B 5/14517 for sweat
• CPC Class Codes: A61B 5/14521 using means for promoting sweat production, e.g. heating the skin measuring sweat secretion A61B5/4266
• CPC Class Codes: A61B 5/4266 sweat secretion
• CPC Class Codes: A61N 1/0428 Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
• CPC Class Codes: A61N 1/325 for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body electrodes for external use A61N1/0428

Abstract

A sweat sensing device includes at least one sweat generation unit capable of initiating sudomotor axon reflex (SAR) sweating in an indirect stimulation region and at least one analysis unit capable of sensing a physiological parameter of sweat, collecting a sweat sample, or a combination thereof. The at least one analysis unit is located above the indirect stimulation region when the sweat sensing device is placed on skin.

Claims

1. A wearable sweat sensing device comprising:

at least one sweat generation unit configured to be placed on a direct stimulation region of a surface of a wearer'"'"'s skin to induce sweating underneath the at least one sweat generation unit, and also to initiate sweating in an indirect stimulation region of skin separated from the direct stimulation region along the skin surface;

at least one sweat collection unit separated from the at least one sweat generation unit by an isolation material, the at least one sweat collection unit capable of collecting one or more sweat samples from the wearer'"'"'s skin, the at least one sweat collection unit being located above the indirect stimulation region when the sweat sensing device is located on the wearer'"'"'s skin to collect sweat sample; and

at least one sensing mechanism in fluid communication with the at least one sweat collection unit for detecting one or more components in the sweat sample.

2. The device of claim 1, wherein the at least one sweat collection unit is separated from the direct stimulation region by a distance of about 0.1 mm to 30 mm.

3. The device of claim 1, wherein the at least one sweat generation unit includes a sweat stimulant for diffusing into skin.

4. The device of claim 3, wherein diffusion of the sweat stimulant is amplified by a diffusive enhancing component.

5. The device of claim 1, wherein the at least one sweat generation unit includes an iontophoresis mechanism and a sweat stimulant.

6. The device of claim 5, wherein the iontophoresis mechanism includes a return electrode placed on a periphery of the sweat collection unit or the sweat generation unit.

7. The device of claim 1, wherein the at least one sensing mechanism is capable of sensing physiological parameters utilizing at least one of potentiometric, amperometric, conductometric, impedance spectroscopy, skin impedance, and galvanic skin response (GSR).

8. The device of claim 1, wherein the at least one sweat collection unit is capable of collecting a sweat sample via capillary action.

9. The device of claim 1, wherein the at least one sweat collection unit includes a material capable of absorbing sweat, a reservoir for collecting sweat, or a combination thereof.

10. The device of claim 1, wherein an arrangement of the at least one sweat generation unit and the at least one sweat collection unit is a hexagonal pattern.

11. The device of claim 1, wherein an arrangement of the at least one sweat generation unit and the at least one sweat collection unit is a concentric pattern.

12. The device of claim 1, wherein the at least one isolation material is an adhesive or rubber.

13. The device of claim 1, further comprising:

at least one wicking material.

14. The device of claim 13, wherein the at least one wicking material is paper.

15. The device of claim 13, wherein the at least one wicking material is polymer-based.

16. The device of claim 13, wherein the at least one wicking material includes at least two materials.

17. The device of claim 13, wherein the at least one wicking material wicks sweat away from at least one analysis unit.

18. The device of claim 13, wherein the at least one wicking material is capable of delivering sweat from skin to at least one analysis unit.

19. The device of claim 13, wherein the at least one wicking material is a volume-limiting pump.

20. The device of claim 1, wherein the at least one sensing mechanism, the at least one sweat collection unit, or a combination of the two, has a greater than unity aspect ratio.

21. The device of claim 1, wherein the at least one sweat generation unit is capable of stimulating sweat by occlusion.

22. The device of claim 1, wherein the at least one sweat generation unit includes a direct-electrical stimulation mechanism.

23. The device of claim 22, wherein the direct-electrical stimulation mechanism includes a return electrode placed on a periphery of the device.

25. The device of claim 1, wherein an indirect sweat stimulation is initiated by sudomotor axon reflex (SAR).

26. The device of claim 25, wherein SAR sweating and sensing and/or collection occurs in at least one instance, continuously for a length of time, or a combination thereof.

27. The device of claim 25, wherein a structure of the at least one sweat collection unit is rectangular to maximize SAR response.

24. A wearable sweat sensing device comprising:

at least one sweat generation unit configured to induce sweat in a direct stimulation region of a wearer'"'"'s skin underneath the sweat generation unit, and initiating sudomotor axon reflex (SAR) sweating in indirect stimulation regions separated from the direct stimulation regions along the wearer'"'"'s skin;

a plurality of sweat collection units configured to be placed spatially within close proximity of the at least one of the sweat generation units to form a honeycomb pattern, the plurality of sweat collection units collecting one or more sweat samples from the wearer'"'"'s skin, each sweat collection unit of the plurality of sweat collection units being located above an indirect stimulation region when the sweat sensing device is placed on the wearer'"'"'s skin; and

at least one sensing mechanism in fluid communication with the plurality of sweat collection units for detecting one or more components in the sweat sample.