Hyaluronic acid-based gels including lidocaine

  • US 10,485,896 B2
  • Filed: 11/09/2018
  • Issued: 11/26/2019
  • Est. Priority Date: 08/04/2008
  • Status: Active Grant
First Claim
Patent Images

1. A dermal filler comprising:

  • hyaluronic acid (HA) crosslinked with 1,4 butanediol diglycidyl ether (BDDE), andlidocaine;

    wherein the lidocaine is freely released in vivo;

    wherein the dermal filler is sterile; and

    wherein the dermal filler is made by a process comprising;

    crosslinking HA with BDDE to obtain a crosslinked HA composition;

    adding lidocaine to the crosslinked HA composition; and

    heat sterilizing the crosslinked HA composition with added lidocaine to obtain a sterile dermal filler.

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