Detection of reduced-control cardiac zones

• US 10,493,294 B2
• Filed: 06/06/2018
• Issued: 12/03/2019
• Est. Priority Date: 09/08/2013
• Status: Active Grant

• Current Assignee: Tylerton International Holdings Inc.
• Original Assignee: Tylerton International Inc.
• Inventors: Ben-Haim, Shlomo
• Primary Examiner(s): Tabatabai, Abolfazl
• Application Number:
  US16/000,962
• Publication Number:
  US 20180280713A1
• Time in Patent Office: 545 Days
• Field of Search: 382128-134, 600300, 600547
• CPC Class Codes: A61B 2018/00577 Ablation
• CPC Class Codes: A61B 34/10 Computer-aided planning, simulation or modelling of surgical operations
• CPC Class Codes: A61B 6/037 Emission tomography
• CPC Class Codes: A61B 6/506 for diagnosis of nerves
• CPC Class Codes: A61N 2/006 for magnetic stimulation of nerve tissue
• CPC Class Codes: A61N 2/02 using magnetic fields produced by coils, including single turn loops or electromagnets A61N2/12 takes precedence
• CPC Class Codes: G06T 2207/10072 Tomographic images
• CPC Class Codes: G06T 2207/10076 4D tomography; Time-sequential 3D tomography
• CPC Class Codes: G06T 2207/30016 Brain
• CPC Class Codes: G06T 2207/30048 Heart; Cardiac
• CPC Class Codes: G06T 2207/30092 Stomach; Gastric
• CPC Class Codes: G06T 7/0012 Biomedical image inspection
• CPC Class Codes: G06T 7/0014 using an image reference approach

Abstract

A method of treating cardiac arrhythmia in a heart, including (i) determining that cardiac tissue is viable but with reduced innervation; and (ii) ablating the tissue to reduce a prevalence of arrhythmia in said heart. Optionally, the determining comprises detecting portions of heart wall which lack electrical activity. Optionally, at least some tissue which is viable but lacks nervous control is ablated, for example, to reduce or avoid arrhythmia.

Claims

1. A computer implemented method for generating an image map of an organ identifying portions of the organ which are viable and have reduced nervous control, comprising:

receiving a first image of the organ, wherein the first image indicates viability of the organ;

receiving a second image of the organ, wherein the second image indicates nervous control of the organ;

identifying, using a data processor, portions of the organ, each being indicated in the first image to be viable, and indicated in the second image to have a level of nervous control below a predetermined threshold or below normal control levels; and

generating, using the data processor, an image map of the organ indicating said identified portions.

2. The method according to claim 1, wherein the first image indicates emissions by a first tracer.

3. The method according to claim 2, wherein the second image indicates emissions by a second tracer.

4. The method of claim 3, wherein the organ is a heart.

5. The method of claim 1, wherein the organ is a heart.

6. The method of claim 1, further comprising:

identifying a level of viability in a region in the first image based on locations of a tracer selectively taken up by viable tissue of the organ.

7. The method of claim 1, further comprising identifying a level of nervous control of the organ based on locations in the second image of a tracer selectively taken up by at least one of the group consisting of nerve endings and tissue which collects adrenaline.

8. The method of claim 1, wherein the first image and the second image are 4-D images.

9. The method of claim 1, wherein:

the autonomic nervous control of the portions of the organ with vital non-neural tissue and reduced autonomic nervous control is reduced relative to a normal level of autonomic nervous control; and

wherein the normal level of autonomic nervous control is provided by an indication of one or more parameter ranges of normal autonomic nervous control comprising at least one of the group consisting of;

a map of normal autonomic nervous control activity ranges allowed for imaged portions of the organ, and

one or more thresholds of autonomic nervous control activity for different parts of the organ.

10. The method of claim 1, wherein the first image and the second image are obtained using dual isotope radioimaging, with a first of the dual isotopes used to identify metabolic activity in the organ, and a second of the dual isotopes used to identify autonomic innervation of the organ based on at least one of the group consisting of activity of presynaptic neurons, the density of receptors for neurotransmitters, and the number of nerve endings.

11. The method of claim 1, wherein the organ comprises the heart of the patient.

12. The method of claim 1, wherein the organ comprises one of the group consisting of:

a liver, a kidney, and an organ of the gastrointestinal tract.

13. The method of claim 1, wherein the indicated nervous control of the organ comprises indication of innervation of the organ.

14. The method of claim 13, wherein the indication of innervation comprises an indication of innervation by one or more autonomic ganglia.

15. The method of claim 1, comprising displaying the map.

16. The method of claim 1, comprising presenting treatment guidance, based on the identified portions indicated in the map.

17. The method of claim 16, wherein the treatment guidance indicates a boundary between at least one of the identified portions indicated in the map and another portion of the organ.

18. The method of claim 16, wherein the treatment guidance indicates a mismatch in activity between at least one of the identified portions indicated in the map and another portion of the organ.