Ablation device with optimized input power profile and method of using the same

• US 10,499,937 B2
• Filed: 05/10/2007
• Issued: 12/10/2019
• Est. Priority Date: 05/19/2006
• Status: Active Grant

• Current Assignee: Recor Medical, Inc. (Otsuka Holdings Company Limited)
• Original Assignee: Recor Medical, Inc. (Otsuka Holdings Company Limited)
• Inventors: Warnking, Reinhard
• Primary Examiner(s): Nguyen, Hien N
• Application Number:
  US12/227,508
• Publication Number:
  US 20100130892A1
• Time in Patent Office: 4,597 Days
• Field of Search: 601 3
• CPC Class Codes: A61B 17/2202 the ultrasound transducer being inside patient's body at the distal end of the catheter
• CPC Class Codes: A61B 18/082 Probes or electrodes therefor
• CPC Class Codes: A61B 18/1492 having a flexible, catheter-like structure, e.g. for heart ablation A61B18/1477 takes precedence
• CPC Class Codes: A61B 2017/22024 with a part reflecting mechanical vibrations, e.g. for focusing
• CPC Class Codes: A61B 2017/22051 with an inflatable part, e.g. balloon, for positioning, blocking, or immobilisation A61B2017/22048, A61B2017/3486 take precedence
• CPC Class Codes: A61B 2018/00244 adapted to separate target tissue from other tissue
• CPC Class Codes: A61B 2018/00351 Heart
• CPC Class Codes: A61B 2018/00702 Power or energy
• CPC Class Codes: A61B 2018/00714 Temperature

Abstract

Ablation device including a probe structure 10 having a proximal end 12 and a distal end 14. Probe structure 10 includes a tubular first catheter 16, a tubular second catheter 18 surrounding the first catheter and a tubular guide catheter extending within the first catheter 16. The first catheter 16 carries a cylindrical ultrasonic transducer 20 adjacent its distal end. The transducer 20 is connected to a source of electrical excitation. The ultrasonic waves emitted by the transducer are directed at the heart wall tissue. Once the tissue reaches the target temperature, the electrical excitation is turned on and off to maintain the tissue at the target temperature. Alternatively, the transducer 20 is subjected to continuous excitation at one power level and upon the tissue reaching the target temperature, the power level of the continuous excitation is switched to a second lower power level.

Claims

1. A method of ablating a volume of target tissue while reducing the risk of ablating untargeted tissue distal to the target tissue, the method comprising:

inserting into a body lumen an ablation catheter comprising at a distal region having an ultrasound transducer configured to emit and deliver energy to target tissue;

providing power at a first level to the ultrasound transducer for a first time duration sufficient to ablate at least a portion of the target tissue so as to create an initial lesion that forms a protective barrier to obstruct subsequently emitted energy traveling toward collateral anatomical structures distal to the initial lesion, and thereby reduces damage to untargeted tissue distal to the target tissue; and

upon completion of the first time duration, modulating power to the ultrasound transducer by cycling between the first power level and a second power level to deliver energy to the target tissue disposed proximal to the protective barrier for a second time duration to completely ablate the volume of target tissue,

wherein modulating power is predetermined empirically.

2. The method of claim 1, wherein the ultrasound transducer is positioned within an interior of an expandable balloon.

3. The method of claim 1, further comprising focusing the ultrasound transducer to deliver energy to a focal region, wherein the focal region comprises the target tissue;

and wherein at least some of the untargeted tissue is proximal to the focal region.

4. The method of claim 1, wherein the first power level is greater than the second power level.

5. The method of claim 4, wherein no energy is delivered at the second power level.

6. The method of claim 1, wherein the target tissue comprises a transmural area of an organ or a blood vessel.