Compositions and methods for treating diseases of the nail

  • US 10,512,640 B2
  • Filed: 12/20/2017
  • Issued: 12/24/2019
  • Est. Priority Date: 01/03/2008
  • Status: Active Grant
First Claim
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1. A method for the treatment of onychomycosis comprising topically applying to the surface of the nail of an individual suffering from onychomycosis a pharmaceutical composition comprising ethanol, diisopropyl adipate, C12-15 alkyl lactate, cyclomethicone, and a triazole antifungal agent;

  • wherein the composition is formulated as a solution;

    wherein the ethanol is present in the composition at a concentration of at least 50% w/w;

    wherein the cyclomethicone is present in the composition at a concentration between 10% and 15% w/w;

    wherein the diisopropyl adipate is present in the composition at a concentration between 8% and 15% w/w;

    wherein the C12-15 alkyl lactate is present in the composition at a concentration between 8% and 15% w/w;

    wherein the composition does not comprise a polymeric film forming compound; and

    wherein the application of the composition is in an amount and for a time sufficient to ameliorate the symptoms of the onychomycosis.

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