Nucleic acids encoding IL-8 antibodies
First Claim
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1. An isolated nucleic acid encoding an anti-IL-8 antibody which comprises a heavy chain variable region (VH) and a light chain variable region (VL), wherein(a) the VH comprises:
- (i) a HVR-H1 comprising the amino acid sequence of SEQ ID NO;
67,(ii) a HVR-H2 comprising the amino acid sequence of SEQ ID NO;
73,(iii) a HVR-H3 comprising the amino acid sequence of SEQ ID NO;
74; and
(b) the VL comprises;
(i) a HVR-L1 comprising the amino acid sequence of SEQ ID NO;
70,(ii) a HVR-L2 comprising the amino acid sequence of SEQ ID NO;
75, and(iii) a HVR-L3 comprising the amino acid sequence of SEQ ID NO;
76.
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Abstract
One nonexclusive aspect provides molecules further improved from antibodies that can bind to antigens in an ion concentration-dependent manner. An alternative nonexclusive aspect provides safe and more advantageous Fc region variants that have decreased binding to pre-existing ADA. An alternative nonexclusive aspect provides novel IL-8 antibodies that are superior as pharmaceuticals.
171 Citations
33 Claims
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1. An isolated nucleic acid encoding an anti-IL-8 antibody which comprises a heavy chain variable region (VH) and a light chain variable region (VL), wherein
(a) the VH comprises: -
(i) a HVR-H1 comprising the amino acid sequence of SEQ ID NO;
67,(ii) a HVR-H2 comprising the amino acid sequence of SEQ ID NO;
73,(iii) a HVR-H3 comprising the amino acid sequence of SEQ ID NO;
74; and(b) the VL comprises; (i) a HVR-L1 comprising the amino acid sequence of SEQ ID NO;
70,(ii) a HVR-L2 comprising the amino acid sequence of SEQ ID NO;
75, and(iii) a HVR-L3 comprising the amino acid sequence of SEQ ID NO;
76. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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15. An isolated nucleic acid encoding an anti-IL-8 antibody which comprises a heavy chain variable region comprising the amino acid sequence of SEQ ID NO:
- 78 and a light chain variable region comprising the amino acid sequence of SEQ ID NO;
79. - View Dependent Claims (16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33)
- 78 and a light chain variable region comprising the amino acid sequence of SEQ ID NO;
Specification