Pulse photometer and method for calculating concentration of light absorber in blood

• US 10,524,704 B2
• Filed: 03/03/2016
• Issued: 01/07/2020
• Est. Priority Date: 03/04/2015
• Status: Active Grant

• Current Assignee: Nihon Kohden Corporation
• Original Assignee: Nihon Kohden Corporation
• Inventors: Ueda, Yoshinori, Ukawa, Teiji, Ito, Kazumasa, Fujisaki, Hideki
• Primary Examiner(s): Winakur, Eric F
• Assistant Examiner(s): Liu, Chu Chuan
• Application Number:
  US15/059,564
• Publication Number:
  US 20160256089A1
• Time in Patent Office: 1,405 Days
• CPC Class Codes: A61B 5/14551 for measuring blood gases
• CPC Class Codes: A61B 5/72 Signal processing specially adapted for physiological signals or for diagnostic purposes character recognition, recognising digital ink, document-oriented image-based pattern recognition G06V30/00; recognition or understanding of postal images G06V30/424

Abstract

A pulse photometer includes: a first variation acquirer acquiring a first variation corresponding to a light attenuation variation of a first light beam due to pulsation of blood in a subject, based on a first intensity signal corresponding to an intensity of the first light beam that is transmitted through or reflected from a body of the subject, and that has a first wavelength; a second variation acquirer acquiring a second variation; and a concentration calculator calculating a blood light absorber concentration, based on the first and second variations, the second variation containing a first offset which is based on an inverse of the light attenuation variation of the first light beam.

Claims

1. A pulse photometer comprising:

a first light emitter which is configured to emit a first light beam having a first wavelength;

a second light emitter which is configured to emit a second light beam having a second wavelength;

a light detector which is configured to output a first intensity signal in accordance with an intensity of the first light beam that is transmitted through or reflected from a body of a subject, and a second intensity signal in accordance with an intensity of the second light beam that is transmitted through or reflected from the body of the subject; and

at least one processor and memory configured to;

acquire a first variation based on the first intensity signal, wherein the first variation corresponds to a light attenuation variation of the first light beam resulting from pulsation of blood in the subject;

acquire a second variation based on the second intensity signal, wherein the second variation corresponds to a light attenuation variation of the second light beam adjusted by a first offset, the light attenuation variation of the second beam resulting from the pulsation of the blood in the subject; and

calculate a blood light absorber concentration, based on the first variation and the second variation,

wherein the first offset is based on an inverse of the light attenuation variation of the first light beam.

2. The pulse photometer according to claim 1, wherein the first offset is a constant that is previously statistically determined based on a plurality of blood light absorber concentrations acquired from a plurality of subjects.

3. The pulse photometer according to claim 1, wherein one of the first light beam and the second light beam is a red light beam, and the other of the first light beam and the second light beam is an infrared light beam.

4. The pulse photometer according to claim 1, further comprising:

a third light emitter,

wherein

the third light emitter is configured to emit a third light beam having a third wavelength,

the light detector is configured to output a third intensity signal in accordance with an intensity of the third light beam that is transmitted through or reflected from the body of the subject,

the at least one processor and memory are further configured to;

acquire a third variation based on the third intensity signal, wherein the third variation corresponds to a light attenuation variation of the third light beam adjusted by a second offset, the light attenuation variation of the third beam resulting from the pulsation of the blood in the subject, and

calculate the blood light absorber concentration, based on the first variation, the second variation, and the third variation, and

the second offset is based on an inverse of the light attenuation variation of the first light beam.

5. The pulse photometer according to claim 4, wherein the second offset is a constant that is previously statistically determined based on a plurality of blood light absorber concentrations acquired from a plurality of subjects.

6. The pulse photometer according to claim 4, wherein the first wavelength, the second wavelength, and the third wavelength are selected from 630 nm, 660 nm, 700 nm, 730 nm, 805 nm, 880 nm, and 940 nm.

7. The pulse photometer according to claim 1, wherein the second variation is identical to the light attenuation variation of the second light beam plus or minus the first offset, and wherein the first variation is identical to the light attenuation variation of the first light beam.

8. The pulse photometer according to claim 1, wherein:

the first variation is substantially equal to Δ

1=ln[I1/(I1−

Δ

I1)], where I1 is the first intensity signal,

the second variation is substantially equal to Δ

2=ln[I2/(I2−

Δ

I2)]+k1, where I2 is the second intensity signal and k1 is the first offset, and

k1 is based on the relationship 1/Δ

1 and is statistically determined based on a plurality of difference values between transcutaneous arterial oxygen saturation and arterial oxygen saturation,

such that the blood light absorber concentration corresponds to Δ

2/Δ

1.

9. The pulse photometer according to claim 1, wherein the first offset is statistically determined based on a plurality of difference values between transcutaneous arterial oxygen saturation and arterial oxygen saturation.

10. A pulse photometer comprising:

at least one processor and memory configured to;

acquire a first variation based on a first intensity signal, wherein the first variation corresponds to a light attenuation variation of a first light beam resulting from pulsation of blood in a subject, the first intensity signal corresponding to an intensity of the first light beam that is transmitted through or reflected from a body of the subject;

acquire a second variation based on a second intensity signal, wherein the second variation corresponds to a light attenuation variation of a second light beam adjusted by a first offset, the light attenuation variation of the second beam resulting from the pulsation of the blood in the subject, the second intensity signal corresponding to an intensity of the second light beam that is transmitted through or reflected from the body of the subject; and

calculate a blood light absorber concentration, based on the first variation and the second variation,

wherein the first offset is based on an inverse of the light attenuation variation of the first light beam.

11. A method for calculating a blood light absorber concentration, the method comprising:

causing a pulse photometer to acquire a first variation based on a first intensity signal, wherein the first variation corresponds to a light attenuation variation of a first light beam resulting from pulsation of blood in a subject, the first intensity signal corresponding to an intensity of the first light beam that is transmitted through or reflected from a body of the subject;

causing the pulse photometer to acquire a second variation based on a second intensity signal, wherein the second variation corresponds to a light attenuation variation of a second light beam adjusted by a first offset, the light attenuation variation of the second beam resulting from the pulsation of the blood in the subject, the second intensity signal corresponding to an intensity of the second light beam that is transmitted through or reflected from the body of the subject; and

causing the pulse photometer to calculate the blood light absorber concentration, based on the first variation and the second variation,

wherein the first offset is based on an inverse of the light attenuation variation of the first light beam.