Hydraulically actuated pump for fluid administration

• US 10,525,194 B2
• Filed: 10/21/2016
• Issued: 01/07/2020
• Est. Priority Date: 04/23/2003
• Status: Active Grant

• Current Assignee: Mannkind Corporation
• Original Assignee: Valeritas, Inc. (Zealand Pharma A/S)
• Inventors: Gonnelli, Robert R., McAllister, Devin V., Levesque, Steven F.
• Primary Examiner(s): Gilbert, Andrew M
• Application Number:
  US15/299,678
• Publication Number:
  US 20170035966A1
• Time in Patent Office: 1,173 Days
• CPC Class Codes: A61M 2005/14264 with means for compensating influence from the environment
• CPC Class Codes: A61M 2005/14506 mechanically driven, e.g. spring or clockwork
• CPC Class Codes: A61M 2005/14513 with secondary fluid driving or regulating the infusion
• CPC Class Codes: A61M 2037/0023 Drug applicators using microneedles
• CPC Class Codes: A61M 2037/0038 having a channel at the side surface
• CPC Class Codes: A61M 2037/0046 Solid microneedles
• CPC Class Codes: A61M 2250/00 Specially adapted for animals
• CPC Class Codes: A61M 37/0015 by using microneedles
• CPC Class Codes: A61M 5/1452 pressurised by means of pistons
• CPC Class Codes: A61M 5/14526 the piston being actuated by fluid pressure
• CPC Class Codes: A61M 5/14593 the diaphragm being actuated by fluid pressure
• CPC Class Codes: A61M 5/155 pressurised by gas introduced into the reservoir
• CPC Class Codes: A61M 5/16877 Adjusting flow; Devices for setting a flow rate
• CPC Class Codes: A61M 60/405 the force acting on the blood contacting member being hydraulic or pneumatic
• CPC Class Codes: F04B 15/02 the fluids being viscous or non-homogeneous
• CPC Class Codes: F04B 53/14 Pistons, piston-rods or piston-rod connections
• CPC Class Codes: F04B 53/16 Casings; Cylinders; Cylinder liners or heads; Fluid connections
• CPC Class Codes: F04B 9/103 having only one pumping chamber
• CPC Class Codes: F04B 9/1095 having two or more pumping chambers in series

Abstract

A fluid delivery device comprises a hydraulic pump chamber having a hydraulic fluid. A fluid reservoir is coupled to the hydraulic pump chamber and is configured to contain a fluid deliverable to a patient. A first actuator is coupled to the hydraulic pump chamber and is configured to pressurize the hydraulic pump chamber and configured to transfer energy through the hydraulic pump chamber to the fluid reservoir. A second actuator is coupled to the hydraulic pump chamber and is configured to pressurize the hydraulic pump chamber and configured to transfer energy through the hydraulic pump chamber to the fluid reservoir.

Claims

1. A fluid delivery device comprising:

a hydraulic pump chamber having a rigid sidewall containing and contacting a first amount of a hydraulic fluid and configured to urge a fluid reservoir piston in a fluid reservoir to deliver fluid within the fluid reservoir to a patient;

a first actuator having a first actuator piston;

a first hydraulic reservoir chamber coupled to the first actuator piston and having a second amount of the hydraulic fluid;

a flow restrictor fluidly coupling the first hydraulic reservoir chamber and the hydraulic pump chamber to one another;

a second hydraulic reservoir chamber having a third amount of the hydraulic fluid and fluidly coupled with the hydraulic pump chamber, independent of the first hydraulic reservoir; and

a second actuator operable independently of the first actuator and having a second actuator piston coupled to the second hydraulic reservoir chamber.

2. The fluid delivery device of claim 1, wherein the flow restrictor limits the transfer of the hydraulic fluid from the first hydraulic reservoir chamber to the hydraulic pump chamber to deliver the fluid from the fluid reservoir at a sustained basal rate.

3. The fluid delivery device of claim 2, wherein the sustained basal rate is constant.

4. The fluid delivery device of claim 2, wherein the sustained basal rate is over a period of more than 5 hours.

5. The fluid delivery device of claim 2, wherein the sustained basal rate is over a period of approximately 24 hours.

6. The fluid delivery device of claim 2, wherein the second actuator is selectably actionable to transfer the hydraulic fluid from the second hydraulic reservoir chamber into the hydraulic pump chamber at discrete intervals to deliver a bolus dosage of the fluid in addition to the sustained basal rate.

7. The fluid delivery device of claim 1, wherein the first and second actuators include compression springs.

8. The fluid delivery device of claim 1, wherein the first and second actuators are coupled to the hydraulic pump chamber in parallel to one another.

9. The fluid delivery device of claim 1, wherein the first actuator includes two or more springs.

10. The fluid delivery device of claim 1, wherein the hydraulic fluid has a viscosity of approximately ISO VG 1500 or more when in use.

11. The fluid delivery device of claim 1, wherein the second hydraulic reservoir is positioned between the second actuator and the hydraulic pump chamber.

12. The fluid delivery device of claim 1, wherein the flow restrictor is a fixed aperture.

13. The fluid delivery device of claim 1 further comprising:

the fluid reservoir piston, the fluid reservoir piston configured to sealingly slide along an inner wall of a hydraulic housing.

14. The fluid delivery device of claim 13, wherein the fluid reservoir piston separates the hydraulic housing into the hydraulic pump chamber and the fluid reservoir.