Vaginal inserted estradiol pharmaceutical compositions and methods

  • US 10,537,581 B2
  • Filed: 10/22/2014
  • Issued: 01/21/2020
  • Est. Priority Date: 12/21/2012
  • Status: Active Grant
First Claim
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1. A pessary consisting of:

  • a) a liquid pharmaceutical composition comprising;

    about 1 μ

    g to about 25 μ

    g of estradiol; and

    a solubilizing agent comprising a medium chain oil;

    wherein the viscosity of the liquid pharmaceutical composition ranges from about 50 cP to about 1000 cP at 25 °

    C., andwherein the liquid pharmaceutical composition does not include a hydrophilic gel-forming bioadhesive agent; and

    b) a soft gelatin capsule encapsulating the liquid pharmaceutical composition;

    wherein estradiol is the only active hormone in the pessary; and

    wherein the pessary is for intravaginal administration.

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