Injector with adjustable dosing

• US 10,543,316 B2
• Filed: 09/22/2015
• Issued: 01/28/2020
• Est. Priority Date: 05/03/2006
• Status: Active Grant

• Current Assignee: Antares Pharma Incorporated
• Original Assignee: Antares Pharma Incorporated
• Inventors: Lesch, Paul R., Rust, Matthew H., Kramer, Thomas E.
• Primary Examiner(s): Desanto, Matthew F
• Application Number:
  US14/860,792
• Publication Number:
  US 20160008543A1
• Time in Patent Office: 1,589 Days
• CPC Class Codes: A61M 2005/2013 triggering of discharging means by contact of injector with patient body
• CPC Class Codes: A61M 2005/206 With automatic needle insertion
• CPC Class Codes: A61M 2005/3125 specific display means, e.g. to indicate dose setting
• CPC Class Codes: A61M 5/2033 Spring-loaded one-shot injectors with or without automatic needle insertion multishot dosing syringes A61M5/31525, needle insertion only A61M5/3287
• CPC Class Codes: A61M 5/30 Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules
• CPC Class Codes: A61M 5/31541 Means preventing setting of a dose beyond the amount remaining in the cartridge
• CPC Class Codes: A61M 5/31553 without axial movement of dose setting member
• CPC Class Codes: A61M 5/31563 interacting with a displaceable stop member
• CPC Class Codes: A61M 5/3158 performed by axially moving actuator operated by user, e.g. an injection button
• CPC Class Codes: A61M 5/31591 Single dose, i.e. individually set dose administered only once from the same medicament reservoir, e.g. including single stroke limiting means
• CPC Class Codes: A61M 5/3202 Devices for protection of the needle before use, e.g. caps A61M5/50 takes precedence; for infusion spikes A61M5/1626; protectors for sharps A61B50/3001
• CPC Class Codes: A61M 5/326 Fully automatic sleeve extension, i.e. in which triggering of the sleeve does not require a deliberate action by the user
• CPC Class Codes: A61M 5/425 Protruding skin to facilitate piercing, e.g. vacuum cylinders, vein immobilising means

Abstract

An injector for injecting a medicament in a patient. The injector includes a container comprising a fluid chamber containing a first volume of a medicament, and an injection conduit associated with the fluid chamber for defining a fluid pathway therefrom to inject the medicament from the fluid chamber through the injection conduit to an injection location. The injector also includes a firing mechanism associated with the fluid chamber for expelling the medicament from the fluid chamber through the injection conduit, and a volume-control mechanism operable to control a fraction of the first volume of medicament that is injected when the firing mechanism is actuated to inject the medicament.

Claims

1. An injection device for injecting medicament in a patient comprising:

a fluid chamber configured to contain a medicament;

a housing configured to house the fluid chamber;

an injection conduit associated with the fluid chamber for defining a fluid pathway from the fluid chamber to the patient;

a firing mechanism associated with the fluid chamber and configured to be actuated to expel the medicament from the fluid chamber through the injection conduit, the firing mechanism comprising;

a ram configured to move with respect to the fluid chamber, thereby dispelling medicament from the fluid chamber, wherein the ram is threaded and is positioned along a longitudinal axis of the injection device;

a trigger having protrusions biased outwardly and in blocking association with the ram in a protecting position; and

a latch housing configured to retain the trigger protrusions in blocking association with the ram in the protecting position and allow the trigger protrusions to disengage from the ram in an injection position; and

a volume control mechanism configured to be adjusted to select a volume of the medicament from the fluid chamber that is injected from the injection conduit when the firing mechanism is actuated, wherein the volume control mechanism includes a stopping member rotatably coupled to the ram and a user engageable control removably coupled to the ram to rotate the ram about the longitudinal axis to select the volume of the medicament to be injected by selectively adjusting the position of the stopping member relative to the ram, wherein adjusting the position of the stopping member includes repositioning the stopping member longitudinally along the ram.

2. The injection device of claim 1, wherein the ram is configured to be biased toward a distal end of the injection device when the firing mechanism is actuated;

wherein the trigger protrusions are resiliently biased outwardly relative to the longitudinal axis of the injection device,

wherein the injection conduit is disposed within a retractable guard when the ram is in the protecting position; and

wherein the latch housing-is configured to move relative to the trigger protrusions to allow the trigger protrusions to move radially outwardly from the blocking association with the ram in the injection position in which a tip of the injection conduit is exposed for injection of the medicament at an injection location.

3. The injection device of claim 2, wherein the retractable guard is positioned at a distal end of the injection device, the retractable guard being moveable between an extended position and a retracted position, wherein the retractable guard is associated with the latch housing such that movement of the retractable guard is configured to slide the latch housing proximately to allow the trigger protrusions to move radially outwardly from the blocking association with the ram, thereby allowing the ram to move with respect to the fluid chamber.

4. The injection device of claim 3, wherein

the stopping member is in threaded association with the threaded ram, wherein the ram is rotatable with respect to the stopping member for selectively positioning the stopping member longitudinally along the ram to select the volume of the medicament to be expelled from the fluid chamber, and

the volume control mechanism further includes a blocking portion positioned to block distal movement of the stopping member associated with the ram when the firing mechanism is actuated to expel the medicament.

5. The injection device of claim 4, wherein the stopping member comprises at least one lateral extension that protrudes laterally from the ram and is configured to be longitudinally aligned with the blocking portion.

6. The injection device of claim 5, wherein the volume control mechanism defines a track that extends generally longitudinally, the lateral extension being slidably received therein, wherein the at least one lateral extension is configured to prevent rotation of the stopping member when the ram is rotated.

7. The injection device of claim 6, wherein the housing defines the track, and wherein the track has a distal end that comprises the blocking member.

8. The injection device of claim 7, wherein the housing includes:

a window adjacent the length of the track such that the longitudinal position of the stopping member within the injection device is visible through the window; and

indicia adjacent the window for determining the volume of the medicament to be injected.

9. The injection device of claim 2, wherein the firing mechanism further comprises an energy source activatable for expelling the medicament.

10. The injection device of claim 9, wherein the injection conduit comprises an injection-assisting needle.

11. The injection device of claim 9, further comprising a bearing member disposed between the energy source and the ram and configured for reducing friction therebetween when the ram is rotated.

12. The injection device of claim 4, wherein the firing mechanism further comprises an energy source activatable for expelling the medicament, and the ram is operably associated with the energy source such that the ram is biased by the energy source when the firing mechanism is activated.

13. The injection device of claim 1, wherein the user engagable control is configured to disengage from the ram when the firing mechanism is actuated.

14. The injection device of claim 13, wherein the user engagable control includes a cap coupled to the housing and a coupling rotationally fixed relative to the ram and is configured to rotate the ram when the cap is rotated, and

wherein the coupling is configured to disengage from the ram when the ram is driven away from the coupling upon activation of the firing mechanism.

15. The injection device of claim 1, wherein the user engageable control is engageable by a user while the device is fully assembled.

16. The injection device of claim 15, wherein the user engageable control is configured to be manually moved to rotate the ram.

17. The injection device of claim 1, wherein the fluid chamber comprises a prefilled syringe, and the injection device further comprises an injection-assisting needle disposed in fluid communication with the fluid chamber, the injection-assisting needle having an injecting tip configured for piercing the patient'"'"'s skin at an injection location.

18. The injection device of claim 1, further comprising a retractable guard disposed at a distal end of the injection device and movable from a needle guard extended position to a needle guard injecting position for activating the firing mechanism.