Advanced analyte sensor calibration and error detection

  • US 10,555,695 B2
  • Filed: 07/02/2019
  • Issued: 02/11/2020
  • Est. Priority Date: 04/15/2011
  • Status: Active Grant
First Claim
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1. A method of making an on-body glucose concentration measuring system for use by a host during a sensor session with a transcutaneously implanted glucose sensor, the method comprising:

  • coating a portion of at least one conductor with a membrane system, wherein the membrane system is sensitive to glucose concentration so as to form at least one transcutaneous glucose sensor having a measurement output parameter sensitive to glucose concentration;

    experimentally measuring a first sensor characteristic of the at least one transcutaneous glucose sensor prior to a sensor session in a host, wherein experimentally measuring the first sensor characteristic comprises measuring in vitro glucose sensitivity characteristics of the at least one glucose sensor in one or more solutions having controlled glucose concentration;

    defining an in vitro glucose concentration sensitivity for the at least one glucose sensor based at least in part on the experimental measurements in the one or more solutions having controlled glucose concentration;

    defining an in vivo glucose concentration sensitivity based at least in part on the defined in vitro sensitivity;

    experimentally measuring a second sensor characteristic of the at least one transcutaneous glucose sensor prior to a sensor session in a host, wherein experimentally measuring the second sensor characteristic comprises measuring a thickness of the membrane system coated onto the at least one transcutaneous glucose sensor; and

    assigning one or more calibration codes to the at least one transcutaneous glucose sensor, wherein the one or more calibration codes are based at least in part on both the defined in vivo sensitivity the at least one transcutaneous glucose sensor and the measured thickness of the membrane system coated onto the at least one transcutaneous glucose sensor.

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