Systems for indicating parameters in an imaging data set and methods of use

• US 10,568,586 B2
• Filed: 10/03/2013
• Issued: 02/25/2020
• Est. Priority Date: 10/05/2012
• Status: Active Grant

• Current Assignee: Volcano Corporation (Koninklijke Philips N.V.)
• Original Assignee: Volcano Corporation (Koninklijke Philips N.V.)
• Inventors: Begin, Elizabeth, Burnett, Joseph, Kemp, Nathaniel J., Nair, Anuja, Glynn, Timothy K., Sproul, Jason
• Primary Examiner(s): Peng, Bo Joseph
• Application Number:
  US14/044,987
• Publication Number:
  US 20140100442A1
• Time in Patent Office: 2,336 Days
• CPC Class Codes: A61B 5/0035 adapted for acquisition of images from more than one imaging mode, e.g. combining MRI and optical tomography
• CPC Class Codes: A61B 5/0066 Optical coherence imaging
• CPC Class Codes: A61B 5/0095 by applying light and detecting acoustic waves, i.e. photoacoustic measurements
• CPC Class Codes: A61B 5/02007 Evaluating blood vessel condition, e.g. elasticity, compliance
• CPC Class Codes: A61B 5/021 Measuring pressure in heart or blood vessels A61B5/0205 takes precedence
• CPC Class Codes: A61B 5/0261 using optical means, e.g. infrared light
• CPC Class Codes: A61B 5/0263 using NMR
• CPC Class Codes: A61B 5/066 Superposing sensor position on an image of the patient, e.g. obtained by ultrasound or x-ray imaging
• CPC Class Codes: A61B 5/489 Blood vessels
• CPC Class Codes: A61B 5/743 Displaying an image simultaneously with additional graphical information, e.g. symbols, charts, function plots
• CPC Class Codes: A61B 5/7435 Displaying user selection data, e.g. icons in a graphical user interface
• CPC Class Codes: A61B 5/7455 characterised by tactile indication, e.g. vibration or electrical stimulation
• CPC Class Codes: A61B 5/746 Alarms related to a physiological condition, e.g. details of setting alarm thresholds or avoiding false alarms alarms per se G08B
• CPC Class Codes: A61B 5/7475 User input or interface means, e.g. keyboard, pointing device, joystick
• CPC Class Codes: A61B 6/12 Arrangements for detecting or locating foreign bodies
• CPC Class Codes: A61B 6/504 for diagnosis of blood vessels, e.g. by angiography
• CPC Class Codes: A61B 8/0841 for locating instruments
• CPC Class Codes: A61B 8/12 in body cavities or body tracts, e.g. by using catheters catheters per se A61M25/00
• CPC Class Codes: A61B 8/14 Echo-tomography
• CPC Class Codes: A61B 8/4416 related to combined acquisition of different diagnostic modalities, e.g. combination of ultrasound and X-ray acquisitions
• CPC Class Codes: A61B 8/465 : adapted to display user selection data, e.g. icons or menus
• CPC Class Codes: A61B 8/466 : adapted to display 3D data 3D imaging and stereoscopic displays in devices for short-range imaging with acoustic waves G01S15/8993 and G01S7/52068, respectively; 3D image rendering G06T15/00; manipulating 3D models for computer graphics G06T19/00
• CPC Class Codes: A61B 8/483 : involving the acquisition of a 3D volume of data
• CPC Class Codes: A61B 8/5223 : for extracting a diagnostic or physiological parameter from medical diagnostic data for algorithms to analyse biomedical images G06T7/0012
• CPC Class Codes: A61B 8/5261 : combining images from different diagnostic modalities, e.g. ultrasound and X-ray
• CPC Class Codes: A61F 2/82 : Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents stent-grafts for tubular structures of the body other than blood vessels A61F2/04; stent-grafts for blood vessels A61F2/07; instruments specially adapted for placement or removal of stents or stent-grafts A61F2/95; for closing wounds, or holding wounds closed A61B17/04 - A61B17/115; dilators A61M29/00
• CPC Class Codes: G01R 33/285 : Invasive instruments, e.g. catheters or biopsy needles, specially adapted for tracking, guiding or visualization by NMR
• CPC Class Codes: G01R 33/4814 : MR combined with ultrasound
• CPC Class Codes: G01R 33/5608 : Data processing and visualization specially adapted for MR, e.g. for feature analysis and pattern recognition on the basis of measured MR data, segmentation of measured MR data, edge contour detection on the basis of measured MR data, for enhancing measured MR data in terms of signal-to-noise ratio by means of noise filtering or apodization, for enhancing measured MR data in terms of resolution by means for deblurring, windowing, zero filling, or generation of gray-scaled images, colour-coded images or images displaying vectors instead of pixels image data processing or generation, in general G06T
• CPC Class Codes: G06T 11/001 : Texturing; Colouring; Generation of texture or colour inpainting G06T5/77
• CPC Class Codes: G06T 19/20 : Editing of 3D images, e.g. changing shapes or colours, aligning objects or positioning parts
• CPC Class Codes: G06T 2210/41 : Medical
• CPC Class Codes: G06T 2219/2012 : Colour editing, changing, or manipulating; Use of colour codes
• CPC Class Codes: G16H 50/30 : for calculating health indices; for individual health risk assessment

Abstract

Systems and methods for aiding users in viewing, assessing and analyzing images, especially images of lumens and medical devices contained within the lumens. Systems and methods for interacting with images of lumens and medical devices, for example through a graphical user interface.

Claims

1. A system for aiding a user in analyzing an imaging data set, the system comprising:

an imaging catheter configured to obtain the imaging data set while the imaging catheter is positioned at a plurality of locations within a lumen of a biological structure, wherein the obtained imaging data set is representative of the lumen of the biological structure and comprises a plurality of two-dimensional intraluminal images obtained at the plurality of locations;

a monitor to display an image associated with the imaging data set;

a central processing unit (CPU); and

storage coupled to the CPU for storing instructions that configure the CPU to;

receive the imaging data set from the imaging catheter;

derive values of a lumen area using the plurality of intraluminal images obtained at the plurality of locations within the lumen;

generate, using the plurality of intraluminal images, a two-dimensional cutaway image including a longitudinal outline of the biological structure, wherein the cutaway image comprises a plurality of longitudinal locations, and wherein each longitudinal location of the cutaway image corresponds to an intraluminal image of the plurality of intraluminal images;

assign, for each of the plurality of longitudinal locations in the cutaway image, an indicator to pixels of the biological structure based on a comparison of the values of the lumen area with a threshold value, wherein the indicator comprises different graphical representations when the value of the lumen area is greater than the threshold value or when the value of the lumen area is less than the threshold value; and

display, on the monitor, the cutaway image and a corresponding graphical representation overlaid on the cutaway image at each of the plurality of longitudinal locations.

2. The system of claim 1, wherein the indicator comprises a plurality of colors.

3. The system of claim 1, wherein the imaging data set is obtained using at least one of optical coherence tomography, intravascular ultrasound, co-registered optical coherence tomography and intravascular ultrasound, co-registered optical coherence tomography and angioscopy, co-registered intravascular ultrasound and angioscopy, spectroscopy, photoacoustic tomography, intravascular magnetic resonance imaging, angioscopy, or combinations thereof.

4. The system of claim 1, wherein the instructions further configure the CPU to assign a second indicator to pixels of the lumen based on a selection of a parameter, a determination of a distribution of values of the selected parameter, a determination of a statistical range associated with the selected parameter, and a comparison of the values of the selected parameter to the statistical range, wherein the parameter is selected from a group consisting of a diameter of a vessel, a vessel remodeling index, a blood flow velocity, a blood pressure, fluid dynamic measurement data, and combinations thereof.

5. The system of claim 1, wherein the cutaway image additionally shows an image of a medical device disposed within the lumen.

6. The system of claim 1, wherein the cutaway image further comprises a dynamic graphical icon configured to modify the image displayed.

7. The system of claim 1, wherein the cutaway image is generated by arranging a plurality of B-scans laid end-to-end.

8. The system of claim 7, wherein the graphical representation comprises outlining a perimeter of the cutaway image, wherein the outline is color coded to indicate values of the lumen area.

9. A system for aiding a user in assessing an imaging data set, the system comprising:

an imaging catheter configured to obtain the imaging data set while the imaging catheter is positioned at a plurality of locations within a lumen of a biological structure, wherein the obtained imaging data set is representative of the lumen of the biological structure and comprises a plurality of two-dimensional intraluminal images obtained at the plurality of locations;

a monitor to display an image associated with the imaging data set;

a central processing unit (CPU); and

storage coupled to the CPU for storing instructions that configure the CPU to;

receive the imaging data set from the imaging catheter;

perform a first analysis of the imaging data set to at least select a parameter associated with the lumen, wherein the parameter is at least one of a diameter of the lumen, a remodeling index of the lumen, a blood flow velocity in the lumen, a blood pressure in the lumen, and fluid dynamic measurement data of the lumen;

perform a second analysis of the imaging data set to derive parameter values based on the selected parameter and using the plurality of two-dimensional intraluminal images, wherein the parameter values are associated with the plurality of locations within the lumen;

generate, using the plurality of intraluminal images, a two-dimensional cutaway image including a longitudinal outline of the biological structure, wherein the cutaway image comprises a plurality of longitudinal locations, and wherein each longitudinal location of the cutaway image corresponds to an intraluminal image of the plurality of intraluminal images;

display the cutaway image on the monitor;

provide the user with a graphical user interface (GUI) on the monitor; and

activate, for each of the plurality of longitudinal locations in the cutaway image, an alert when the user interacts with a longitudinal location on the cutaway image that corresponds to a location at which imaging data of the imaging data set was obtained, wherein the alert includes pixels of the lumen based on a comparison of the values of the selected parameter within the lumen with a threshold value, wherein the alert comprises different graphical representations when the parameter value is greater than the threshold value or when the parameter value is less than the threshold value.

10. The system of claim 9, wherein the imaging data set is obtained with a technique selected from a group comprising optical coherence tomography, intravascular ultrasound, co-registered optical coherence tomography and intravascular ultrasound, co-registered optical coherence tomography and angioscopy, co-registered intravascular ultrasound and angioscopy, spectroscopy, photoacoustic tomography, intravascular magnetic resonance imaging, angioscopy, and combinations thereof.

11. The system of claim 9, wherein a stent is disposed within the lumen, and wherein the instructions further configure the CPU to activate a second alert when the user interacts with the cutaway image or a portion of the cutaway image that include pixels having values of a second parameter falling outside a statistical range associated with the second parameter, wherein the statistical range associated with the second parameter is determined based on a distribution of values of the second parameter, wherein the distribution is determined based on values of the second parameter, wherein the parameter is selected from a group comprising an area of the lumen, a thickness of a lumen wall, a plaque buildup in the lumen, a size of a thrombus in the lumen, a location of a thrombus in the lumen, a stent apposition in the lumen, a stent coverage of the lumen, a stent fracture amount, a stent placement location within the lumen, and combinations thereof.

12. The system of claim 9, wherein the instructions further comprise:

displaying a dynamic graphical icon based on the parameter.

13. The system of claim 9, wherein the alert is selected from a group comprising a visual alert, an audio alert, a haptic alert, a dynamic gauge indicator alert, and combinations thereof.

14. The system of claim 13, wherein, when the alert activated is a visual alert, the visual alert is selected from a group comprising a color-coded indicator, a pulsating indicator, a color map of the selected parameter, an altered-sized lumen image, an altered-sized parameter encoded in a lumen image, a gauge, a callout marker, and combinations thereof.

15. The system of claim 13, wherein the system additionally comprises a pointing device for interacting with the monitor, and, when the alert activated is a haptic alert, the haptic alert comprises a vibration in the pointing device.

16. The system of claim 9, wherein the user interacts with the cutaway image or a portion of the cutaway image by moving an indicator along a length of the displayed image or a length of the portion of the displayed image.

17. A system for aiding a user in assessing an imaging data set, the system comprising:

an imaging catheter configured to obtain the imaging data set while being positioned within a vessel of a biological structure, wherein the imaging catheter is further configured to translate in the vessel while obtaining the imaging data set representative of the vessel of the biological structure at a plurality of locations, and wherein the imaging data set comprises a plurality of two-dimensional intraluminal images obtained at a plurality of locations;

a monitor to display an image associated with the imaging data set;

a central processing unit (CPU); and

storage coupled to the CPU for storing instructions that configure the CPU to;

receive the imaging data set from the imaging catheter;

perform a first analysis of the imaging data set obtained by the imaging catheter to derive a plurality of parameter values based on a selected parameter and associated with a plurality of locations within the vessel, wherein the parameter comprises a lumen area, and wherein the plurality of parameter values are derived using the plurality of two-dimensional intraluminal images;

perform a second analysis of the plurality of parameter values of the selected parameter within the vessel to automatically determine a threshold value associated with the selected parameter;

generate, using the plurality of intraluminal images, a two-dimensional cutaway image including a longitudinal outline of the biological structure, wherein the cutaway image comprises a plurality of longitudinal locations, and wherein each longitudinal location of the cutaway image corresponds to an intraluminal image of the plurality of intraluminal images;

display, on the monitor, the cutaway image and indicators, for each of the plurality of longitudinal locations, corresponding to one or more of the parameter values of the selected parameter based, at least in part, on a comparison of the parameter values with the threshold value, wherein the indicator comprises different graphical representations when the parameter value is greater than the threshold value or when the parameter value is less than the threshold value;

provide the user with a graphical user interface (GUI) on the monitor; and

display a value of the parameter when the user interacts with the cutaway image of the vessel.

18. The system of claim 17, wherein the instructions additionally configure the CPU to display a second intraluminal image when the user interacts with the cutaway image.

19. The system of claim 18, wherein the second intraluminal image is a cross-sectional view of the vessel.

20. A system for aiding a user in assessing an imaging data set, the system comprising:

an imaging catheter configured to obtain the imaging data set while being positioned within a lumen of a biological structure, wherein the imaging catheter is further configured to translate in the lumen while obtaining the imaging data set representative of the lumen of the biological structure at a plurality of locations, and wherein the imaging data set comprises a plurality of two-dimensional intraluminal images obtained at a plurality of locations;

a monitor to display an image associated with the imaging data set;

a central processing unit (CPU); and

storage coupled to the CPU for storing instructions that configure the CPU to;

receive the imaging data set from the imaging catheter;

perform a first analysis of the imaging data set to derive a plurality of parameter values based on a selected parameter and associated with a plurality of locations within the lumen, wherein the parameter is selected from a group comprising a diameter of the lumen, a lumen remodeling index, a blood flow velocity in the lumen, a blood pressure in the lumen, and fluid dynamic measurement data of the lumen, and wherein the plurality of parameter values are derived using the plurality of two-dimensional intraluminal images;

perform a second analysis of the plurality of parameter values of the selected parameter associated with the plurality of locations within the lumen to automatically determine a threshold value associated with the selected parameter;

generate, using the plurality of intraluminal images, a two-dimensional cutaway image including a longitudinal outline of the biological structure, wherein the cutaway image comprises a plurality of longitudinal locations, and wherein each longitudinal location of the cutaway image corresponds to an intraluminal image of the plurality of intraluminal images;

display, on the monitor, the cutaway image and indicators, for each of the plurality of longitudinal locations, corresponding to one or more of the parameter values of the selected parameter based, at least in part, on a comparison of the parameter values with the threshold value, wherein the indicator comprises different graphical representations when the parameter value is greater than the threshold value or when the parameter value is less than the threshold value;

provide the user with a graphical user interface (GUI) on the monitor; and

display a second intraluminal image when the user interacts with the cutaway image.

21. The system of claim 20, wherein the second intraluminal image is a cross-sectional view of the lumen.

22. The system of claim 20, further comprising superimposing an image of a medical device configured to be disposed within the lumen on the cutaway image or the second intraluminal image.