Implants using ultrasonic backscatter for sensing physiological conditions
First Claim
1. A system, comprising:
- (a) an implantable device, comprising;
a sensor configured to detect an amount of strain or an amount of pressure; and
an ultrasonic transducer with a length of 5 mm or less in the longest dimension, the ultrasonic transducer configured to receive ultrasonic waves that power the implantable device, receive a current modulated based on the amount of pressure or the amount of strain detected by the sensor, and emit a strain-dependent or pressure-dependent ultrasonic backscatter based on the current received by the ultrasonic transducer; and
(b) an interrogator comprising one or more ultrasonic transducers configured to transmit the ultrasonic waves that power the implantable device, and receive the ultrasonic backscatter from the implantable device.
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Accused Products
Abstract
Described herein is an implantable device having a sensor configured to detect an amount of an analyte, a pH, a temperature, strain, or a pressure; and an ultrasonic transducer with a length of about 5 mm or less in the longest dimension, configured to receive current modulated based on the analyte amount, the pH, the temperature, or the pressure detected by the sensor, and emit an ultrasonic backscatter based on the received current. The implantable device can be implanted in a subject, such as an animal or a plant. Also described herein are systems including one or more implantable devices and an interrogator comprising one or more ultrasonic transducers configured to transmit ultrasonic waves to the one or more implantable devices or receive ultrasonic backscatter from the one or more implantable devices. Also described are methods of detecting an amount of an analyte, a pH, a temperature, a strain, or a pressure.
120 Citations
30 Claims
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1. A system, comprising:
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(a) an implantable device, comprising; a sensor configured to detect an amount of strain or an amount of pressure; and an ultrasonic transducer with a length of 5 mm or less in the longest dimension, the ultrasonic transducer configured to receive ultrasonic waves that power the implantable device, receive a current modulated based on the amount of pressure or the amount of strain detected by the sensor, and emit a strain-dependent or pressure-dependent ultrasonic backscatter based on the current received by the ultrasonic transducer; and (b) an interrogator comprising one or more ultrasonic transducers configured to transmit the ultrasonic waves that power the implantable device, and receive the ultrasonic backscatter from the implantable device. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21)
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22. A method of detecting an amount of strain or an amount of pressure, comprising:
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powering an implantable device implanted in a subject using ultrasonic waves emitted from an interrogator comprising one or more ultrasonic transducers, wherein the implantable device comprises an ultrasonic transducer with a length of 5 mm or less in the longest dimension and a sensor configured to measure the amount of pressure or the amount of strain; converting energy from the ultrasonic waves into an electrical current; measuring the amount of strain or the amount of pressure using the sensor; producing a modulated electrical current based on the measured amount strain or the measured amount of pressure; transducing the modulated electrical current into an ultrasonic backscatter that encodes the measured amount of strain or the measured amount of pressure; emitting the ultrasonic backscatter to the interrogator; and receiving the ultrasonic backscatter. - View Dependent Claims (23, 24, 25, 26, 27, 28)
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29. A system for measuring intra-ocular pressure, comprising:
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(a) an implantable device, comprising; a sensor configured to detect an amount of intra-ocular pressure; and an ultrasonic transducer with a length of 5 mm or less in the longest dimension, the ultrasonic transducer configured to receive ultrasonic waves that power the implantable device, receive a current modulated based on the amount of pressure or the amount of strain detected by the sensor, and emit a strain-dependent or pressure-dependent ultrasonic backscatter based on the current received by the ultrasonic transducer; and (b) an interrogator comprising one or more ultrasonic transducers configured to transmit the ultrasonic waves that power the implantable device, and receive the ultrasonic backscatter from the implantable device.
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30. A method of measuring intra-ocular pressure, comprising:
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powering one or more implantable devices implanted in a subject using ultrasonic waves emitted from an interrogator comprising one or more transducers, wherein the one or more implantable devices comprise an ultrasonic transducer with a length of 5 mm or less in the longest dimension and a sensor configured to measure the amount of intra-ocular pressure; converting energy from the ultrasonic waves into an electrical current; measuring the amount of intra-ocular pressure using the sensor; producing a modulated electrical current based on the measured amount of intra-ocular pressure; transducing the modulated electrical current into an ultrasonic backscatter that encodes the measured amount of intra-ocular pressure; emitting the ultrasonic backscatter to the interrogator; and receiving the ultrasonic backscatter.
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Specification