Pharmaceutical composition for reducing local fat and uses thereof
First Claim
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1. A subcutaneous injection formulation to be administered at a local site of a subject, comprising:
- a curcumin; and
a pharmaceutically acceptable polyoxyethylene castor oil derivative;
wherein, the weight ratio of the curcumin to the polyoxyethylene castor oil derivative is 1;
8˜
1;
500;
the pharmaceutically acceptable polyoxyethylene castor oil derivative and the curcumin together form a plurality of curcumin-containing micelles, and the hydrophilic-lipophilic balance value (HLB value) of the polyoxyethylene castor oil derivative is greater than 10.
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Abstract
The present invention provides a pharmaceutical composition for reducing localized fat, comprising drug-containing micelles made of surfactants, and curcumin encapsulated in said drug-containing micelles. This pharmaceutical composition for reducing localized fat can reduce the fat at the administration site, and has the advantages of high stability, high bioavailability for fat tissue, few side effects, and sustained release.
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18 Claims
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1. A subcutaneous injection formulation to be administered at a local site of a subject, comprising:
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a curcumin; and a pharmaceutically acceptable polyoxyethylene castor oil derivative; wherein, the weight ratio of the curcumin to the polyoxyethylene castor oil derivative is 1;
8˜
1;
500;
the pharmaceutically acceptable polyoxyethylene castor oil derivative and the curcumin together form a plurality of curcumin-containing micelles, and the hydrophilic-lipophilic balance value (HLB value) of the polyoxyethylene castor oil derivative is greater than 10. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18)
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Specification