Insulin delivery methods, systems and devices

• US 10,610,644 B2
• Filed: 01/12/2018
• Issued: 04/07/2020
• Est. Priority Date: 01/13/2017
• Status: Active Grant

• Current Assignee: Insulet Corporation
• Original Assignee: Bigfoot Biomedical, Inc.
• Inventors: Mazlish, Bryan, Desborough, Lane
• Primary Examiner(s): Mendez, Manuel A
• Application Number:
  US15/870,686
• Publication Number:
  US 20180200439A1
• Time in Patent Office: 816 Days
• CPC Class Codes: A61B 5/0024 for multiple sensor units attached to the patient, e.g. using a body or personal area network
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61M 2230/201 Glucose concentration
• CPC Class Codes: A61M 5/14244 adapted to be carried by the patient, e.g. portable on the body
• CPC Class Codes: A61M 5/1723 using feedback of body parameters, e.g. blood-sugar, pressure measurement of body parameters A61B5/00
• CPC Class Codes: G16H 20/17 delivered via infusion or injection

Abstract

Methods of insulin delivery may include obtaining one or more blood glucose readings from a flash glucose monitor, where the blood glucose readings may be obtained in response to a user invocation of the flash glucose monitor. The method may also include generating multiple insulin delivery profiles of insulin delivery actions over multiple diurnal time segments based on the one or more blood glucose readings. The method may additionally include selecting one of the delivery profiles that is projected to approximate a target blood glucose level, and delivering insulin according to the selected delivery profile. Systems may provide such insulin delivery.

Claims

1. A method of insulin delivery, the method comprising:

obtaining one or more blood glucose readings from a flash glucose monitor, the blood glucose readings obtained in response to a user invocation of the flash glucose monitor;

generating a plurality of insulin delivery profiles of insulin delivery actions over a plurality of diurnal time segments based on the one or more blood glucose readings;

selecting one of the plurality of insulin delivery profiles that is projected to approximate a target blood glucose level; and

providing the selected delivery profile to be utilized with an insulin delivery device to deliver the selected delivery profile to the user.

2. The method of claim 1, further comprising adjusting one or more user-specific diurnal-specific parameters based on the selected delivery profile.

3. The method of claim 2, further comprising excluding one or more diurnal time segments from having associated user-specific diurnal-specific parameters adjusted based on the flash glucose monitor not being invoked during the one or more excluded diurnal time segments.

4. The method of claim 1, further comprising receiving the one or more blood glucose monitor readings from the flash glucose monitor in response to the user invoking the flash glucose monitor.

5. The method of claim 1, further comprising exiting a closed-loop delivery mode such that the selected delivery profile delivers a predetermined baseline basal rate based on a predetermined period of time elapsing without invocation of the flash glucose monitor.

6. The method of claim 1, further comprising entering a closed-loop delivery mode based on the user invoking the flash glucose monitor.

7. The method of claim 6, wherein the closed-loop delivery mode is one of a hybrid closed-loop mode and a full closed-loop mode.

8. The method of claim 1, further comprising delivering insulin according to the selected delivery profile with the insulin delivery device.

9. A method of insulin delivery, the method comprising:

obtaining one or more blood glucose readings from a flash glucose monitor, the blood glucose readings obtained in response to a request of the flash glucose monitor;

generating a plurality of insulin delivery profiles of insulin delivery actions over a plurality of diurnal time segments based on the one or more blood glucose readings;

selecting one of the plurality of insulin delivery profiles that is projected to approximate a target blood glucose level; and

providing the selected delivery profile to be utilized with an insulin delivery device to deliver the selected delivery profile to a user.

10. An insulin delivery system comprising:

an insulin delivery device configured to deliver insulin to a user;

a flash glucose monitor configured to obtain one or more blood glucose readings from the user; and

a controller configured to perform or control performance of operations, the operations comprising;

obtaining one or more blood glucose readings from the flash glucose monitor;

generating a plurality of insulin delivery profiles of insulin delivery actions over a plurality of diurnal time segments based on the one or more blood glucose readings;

selecting one of the plurality of insulin delivery profiles that is projected to approximate a target blood glucose level; and

providing the selected delivery profile to be utilized with the insulin delivery device to deliver a least a portion of the selected delivery profile to the user.

11. The system of claim 10, wherein the operations further comprise delivering insulin according to the selected delivery profile with the insulin delivery device.

12. The system of claim 10, wherein the insulin delivery device comprises an insulin pump assembly configured to supply an at least partially continuous subcutaneous insulin infusion therapy to the user.

13. The system of claim 10, wherein the insulin delivery device comprises a bolus administering device configured to supply discrete insulin doses to the user.

14. The system of claim 13, wherein the bolus administering device comprises an insulin pen.

15. The system of claim 10, wherein the controller is integrated with the insulin delivery device.

16. The system of claim 10, wherein the controller comprises a separate device from the insulin delivery device.

17. The system of claim 16, wherein the separate device of the controller is configured to communicate with the insulin delivery device to provide the selected delivery profile.

18. The system of claim 10, wherein the controller is configured to enable a user to at least one of modify or input data relating to the selected delivery profile.

19. The system of claim 10, the flash glucose monitor is configured to provide the blood glucose readings in response to a user request of the flash glucose monitor.

20. The system of claim 19, the flash glucose monitor is configured to be invoked via near field communication (NFC) by the user.