Porogen compositions, methods of making and uses

• US 10,624,997 B2
• Filed: 12/04/2015
• Issued: 04/21/2020
• Est. Priority Date: 02/05/2010
• Status: Active Grant

• Current Assignee: Allergan, Inc. (Canada) (Abbvie Incorporated)
• Original Assignee: Allergan, Inc. (Canada) (Abbvie Incorporated)
• Inventors: Liu, Futian, Manesis, Nicholas J., Yu, Xiaojie, Chan, Athene W.
• Primary Examiner(s): Salamon, Peter A
• Application Number:
  US14/960,075
• Publication Number:
  US 20160151542A1
• Time in Patent Office: 1,600 Days
• Field of Search: None
• CPC Class Codes: A61F 2/12 Mammary prostheses and implants
• CPC Class Codes: A61L 24/001 Use of materials characterised by their function or physical properties
• CPC Class Codes: A61L 24/0036 Porous materials, e.g. foams or sponges
• CPC Class Codes: A61L 2400/18 Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment
• CPC Class Codes: A61L 27/18 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: A61L 27/20 Polysaccharides
• CPC Class Codes: A61L 27/26 Mixtures of macromolecular compounds
• CPC Class Codes: A61L 27/34 Macromolecular materials
• CPC Class Codes: A61L 27/56 Porous materials, e.g. foams or sponges
• CPC Class Codes: A61L 28/0034 Use of materials characterised by their function or physical properties
• CPC Class Codes: A61L 28/0053 Porous materials, e.g. foams or sponges
• CPC Class Codes: A61L 31/041 Mixtures of macromolecular compounds
• CPC Class Codes: A61L 31/042 Polysaccharides
• CPC Class Codes: A61L 31/06 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds A61L31/041 takes precedence
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61L 31/14 Materials characterised by their function or physical properties , e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
• CPC Class Codes: A61L 31/146 Porous materials, e.g. foams or sponges
• CPC Class Codes: B29C 41/14 Dipping a core B29C41/10 takes precedence
• CPC Class Codes: B29C 41/22 Making multilayered or multicoloured articles
• CPC Class Codes: Y10T 428/2989 Microcapsule with solid core [includes liposome]

Abstract

The present specification discloses porogen compositions comprising a core material and shell material, methods of making such porogen compositions, methods of forming such porous materials using such porogen compositions, biocompatible implantable devices comprising such porous materials, and methods of making such biocompatible implantable devices.

Claims

1. An uncured elastomer/porogen mixture comprising an elastomer and a porogen composition for coating a biocompatible implantable device, the porogen composition comprising a core material and a shell material, wherein the core material comprises at least two compounds, wherein the shell material has a melting temperature that is lower than a melting temperature of the core material, and wherein the shell material is adjacent to the core material, and the elastomer is selected from a group consisting of:

bromo isobutylene isoprene (BIIR), polybutadiene (BR), chloro isobutylene isoprene (CIIR), polychloroprene (CR), chlorosulphonated polyethylene (CSM), ethylene propylene (EP), ethylene propylene diene monomer (EPDM), fluorinated hydrocarbon (FKM), fluoro silicone (FVQM), hydrogenated nitrile butadiene (HNBR), polyisoprene (IR), isobutylene isoprene butyl (IIR), methyl vinyl silicone (MVQ), acrylonitrile butadiene (NBR), polyurethane (PU), styrene butadiene (SBR), styrene ethylene/butylene styrene (SEBS), and acrylonitrile butadiene carboxy monomer (XNBR).

2. The mixture of claim 1, wherein the core material comprises a sugar or a derivative thereof, a polysaccharide sugar or a derivative thereof, a composite thereof, or a combination thereof.

3. The mixture of claim 1, wherein the core material comprises sucrose and starch.

4. The mixture of claim 3, wherein the shell material comprises polyethylene glycol.

5. The mixture of claim 3, wherein the porogen composition comprises about 35% to about 50% sucrose, about 10% to about 15% starch, and about 40% to 50% polyethylene glycol, by weight.

6. The mixture of claim 5, wherein the porogen composition comprises about 45% sucrose, about 10% starch, and about 45% polyethylene glycol, by weight.

7. The mixture of claim 5, wherein the porogen composition comprises about 40% sucrose, about 15% starch, and about 45% polyethylene glycol, by weight.

8. The mixture of claim 3, wherein the porogen composition comprises a mean porogen diameter of about 300 μ

m to about 650 μ

m.

9. The mixture of claim 8, wherein the porogen composition comprises a mean porogen diameter of about 550 μ

m.

10. An uncured elastomer/porogen mixture comprising an elastomer and a porogen composition for coating a biocompatible implantable device, the porogen composition comprising a core material and a shell material, wherein the core material comprises at least two compounds, wherein under a given physical or physicochemical treatment the shell material transitions from a solid phase to a liquid phase and the core material remains in a solid phase, and wherein the shell material is adjacent to the core material, and the elastomer is selected from a group consisting of:

bromo isobutylene isoprene (BIIR), polybutadiene (BR), chloro isobutylene isoprene (CIIR), polychloroprene (CR), chlorosulphonated polyethylene (CSM), ethylene propylene (EP), ethylene propylene diene monomer (EPDM), fluorinated hydrocarbon (FKM), fluoro silicone (FVQM), hydrogenated nitrile butadiene (HNBR), polyisoprene (IR), isobutylene isoprene butyl (IIR), methyl vinyl silicone (MVQ), acrylonitrile butadiene (NBR), polyurethane (PU), styrene butadiene (SBR), styrene ethylene/butylene styrene (SEBS), and acrylonitrile butadiene carboxy monomer (XNBR).

11. The mixture of claim 10, wherein the shell fusion occurs by a physical state change from solid phase to liquid or rubbery phase.

12. The mixture of claim 10, wherein the shell material comprises at least two compounds.

13. The mixture of claim 10, wherein the core material comprises a sugar or a derivative thereof, a polysaccharide or a derivative thereof, a composite thereof, or a combination thereof.

14. The mixture of claim 10, wherein the core material comprises sucrose and starch.

15. The mixture of claim 10, wherein the shell material comprises polyethylene glycol.

16. The mixture of claim 14, wherein the porogen composition comprises about 35% to about 50% sucrose, about 10% to about 15% starch, and about 40% to 50% polyethylene glycol, by weight.

17. The mixture of claim 16, wherein the porogen composition comprises about 45% sucrose, about 10% starch, and about 45% polyethylene glycol, by weight.

18. The mixture of claim 16, wherein the porogen composition comprises about 40% sucrose, about 15% starch, and about 45% polyethylene glycol, by weight.

19. The mixture of claim 14, wherein the porogen composition comprises a mean porogen diameter of about 300 μ

m to about 650 μ

m.

20. The mixture of claim 19, wherein the porogen composition comprises a mean porogen diameter of about 550 μ

m.