Methods, devices, and systems for blood flow

• US 10,639,085 B2
• Filed: 12/12/2017
• Issued: 05/05/2020
• Est. Priority Date: 05/06/2016
• Status: Active Grant

• Current Assignee: Medos International Sarl (Johnson & Johnson)
• Original Assignee: Medos International Sarl (Johnson & Johnson)
• Inventors: Whittaker, Gregory R., Cleveland, Benjamin, Hwang, Julia, Spenciner, David B., Parrish, William R., Sengun, Mehmet Z., Theis, Reagan A.
• Primary Examiner(s): Wax, Robert A
• Assistant Examiner(s): Mercier, Melissa S
• Application Number:
  US15/838,781
• Publication Number:
  US 20180098803A1
• Time in Patent Office: Days
• Field of Search: None
• CPC Class Codes: A61B 17/0401 Suture anchors, buttons or pledgets, i.e. means for attaching sutures to bone, cartilage or soft tissue; Instruments for applying or removing suture anchors A61B17/0642 takes precedence; fixation devices for tendons or ligaments A61F2/0811
• CPC Class Codes: A61B 17/846 Nails or pins, i.e. anchors without movable parts, holding by friction only, with or without structured surface A61B17/72, A61B17/86 take precedence
• CPC Class Codes: A61B 2017/00004 (bio)absorbable, (bio)resorbable, resorptive for implantable prostheses A61F2210/0004
• CPC Class Codes: A61B 2017/0412 having anchoring barbs or pins extending outwardly from suture anchor body
• CPC Class Codes: A61B 2017/044 with a threaded shaft, e.g. screws
• CPC Class Codes: A61B 2017/0445 cannulated, e.g. with a longitudinal through-hole for passage of an instrument
• CPC Class Codes: A61B 2017/045 snug fit within the anchor
• CPC Class Codes: A61B 2017/0458 Longitudinal through hole, e.g. suture blocked by a distal suture knot
• CPC Class Codes: A61B 2017/561 Implants with special means for releasing a drug
• CPC Class Codes: A61F 2/0811 Fixation devices for tendons or ligaments
• CPC Class Codes: A61L 2300/42 Anti-thrombotic agents, anticoagulants, anti-platelet agents
• CPC Class Codes: A61L 2430/02 for reconstruction of bones; weight-bearing implants
• CPC Class Codes: A61L 27/28 Materials for coating prostheses
• CPC Class Codes: A61L 27/34 Macromolecular materials
• CPC Class Codes: A61L 27/58 Materials at least partially resorbable by the body
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: A61M 2025/0057 Catheters delivering medicament other than through a conventional lumen, e.g. porous walls or hydrogel coatings
• CPC Class Codes: A61M 25/0043 characterised by structural features

Abstract

Various exemplary methods, systems, and devices for blood flow are provided. In general, an implant can be configured to be implanted in bone and to delay clotting of blood flowing from the bone. The implant can include an anti-coagulation agent to delay the clotting of the blood. The anti-coagulation agent can be a coating on the implant, can be natural to a material forming the implant, or can be impregnated into a material forming the implant. In an exemplary embodiment, the implant is implanted in a bone in a surgical procedure for securing a soft tissue to bone, such as a rotator cuff repair procedure or an anterior cruciate ligament (ACL) repair procedure.

Claims

1. A surgical device, comprising:

a one-piece biocompatible anchor configured to be implanted in a bone of a patient, the anchor not being bioabsorbable, the anchor having at least one bone-engaging surface feature on an exterior surface thereof that is configured to engage the bone and thereby secure the anchor in the bone, the anchor having an inner lumen extending therethrough configured to allow blood to flow into the inner lumen through a first open end of the inner lumen and out of the inner lumen through a second open end of the inner lumen when the anchor is implanted in the bone, and the anchor including an anti-coagulation agent, the at least one bone-engaging surface feature including a first flange, which extends radially outward from a proximal end of the anchor in which the first open end is formed, and a second flange, which extends radially outward from a distal end of the anchor in which the second open end is formed, wherein the anchor has a solid sidewall defining an entire length of the inner lumen through which the blood can flow in the anchor and that thereby limits blood that flows into the inner lumen through the first open end from exiting the inner lumen only through the first open end or the second open end.

2. The device of claim 1, wherein the anti-coagulation agent is coated on a surface of the anchor.

3. The device of claim 1, wherein the anti-coagulation agent is impregnated in a material forming the anchor.

4. The device of claim 1, wherein the anti-coagulation agent includes at least one of heparin, heparin sulfate, warfarin, hirudin, hirulog, coumarin, phosphorylcholine, indiandione, antithrombin III, bemiparin, dalteparin, danaparoid, enoxaparin, nadroparin, parnaparin, reviparin, sulodexide, tinzaparin, anticoagulant citrate dextrose solution A (ACD-A), ethylenediaminetetraacetic acid (EDTA), citrate, oxalate, a factor Xa inhibitor, and a thrombin inhibitor.

5. The device of claim 1, wherein a suture coated with or impregnated with an anti-coagulation agent is coupled to the anchor.

6. The device of claim 1, wherein the anchor includes a body having a first maximum diameter, and the first flange has a second maximum diameter that is greater than the first maximum diameter.

7. The device of claim 1, wherein the flanges each extend around an entire perimeter of the body.

8. A surgical device, comprising:

a biocompatible anchor configured to be implanted in a bone of a patient with an inner lumen extending through the anchor being open and free of occlusions, the inner lumen extending through the anchor such that blood can flow into the inner lumen through a first open end of the inner lumen and out of the inner lumen through a second open end of the inner lumen when the anchor is implanted in the bone, the anchor including an anti-coagulation agent;

wherein the anchor includes a body and a flange integrally formed with the body, the flange extends radially outward from the body around an entire perimeter of the body at a fixed axial position along a longitudinal axis of the body, the body has a first maximum diameter, and the flange has a second maximum diameter that is greater than the first maximum diameter.

9. The device of claim 8, wherein the anti-coagulation agent is coated on a surface of the anchor.

10. The device of claim 8, wherein the anti-coagulation agent is impregnated in a material forming the anchor.

11. The device of claim 8, wherein the anti-coagulation agent includes at least one of heparin, heparin sulfate, warfarin, hirudin, hirulog, coumarin, phosphorylcholine, indiandione, antithrombin III, bemiparin, dalteparin, danaparoid, enoxaparin, nadroparin, parnaparin, reviparin, sulodexide, tinzaparin, anticoagulant citrate dextrose solution A (ACD-A), ethylenediaminetetraacetic acid (EDTA), citrate, oxalate, a factor Xa inhibitor, and a thrombin inhibitor.

12. The device of claim 8, wherein the anchor has a solid sidewall defining the inner lumen through which the blood flows.

13. The device of claim 8, wherein the anchor has at least one hole formed through a sidewall thereof, and the at least one hole being in communication with the inner lumen such that the blood can flow into the inner lumen through the at least one hole.

14. The device of claim 8, wherein the first open end of the inner lumen is at a proximal end of the anchor;

the second open end of the inner lumen is at a distal end of the anchor; and

the axial position of the flange is at a same axial position as the first open end of the inner lumen and surrounds the first open end of the inner lumen.

15. The device of claim 8, wherein the first open end of the inner lumen is at a proximal end of the anchor;

the second open end of the inner lumen is at a distal end of the anchor; and

the axial position of the flange is located in an intermediate portion of the body between axial positions of the first and second open ends of the inner lumen.