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Analysis compensation including segmented signals converted into signal processing parameters for describing a portion of total error

  • US 10,646,445 B2
  • Filed: 08/29/2017
  • Issued: 05/12/2020
  • Est. Priority Date: 09/21/2011
  • Status: Active Grant
First Claim
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1. A method of operating a biosensor system, the method comprising:

  • providing a biosensor system in the form of an analytical instrument includinga measurement device having electrical circuitry communicatively coupled to a processor, a storage medium, a signal generator, and a sensor interface, the processor having instructions and data stored in the storage medium, anda test sensor having a base and a sample interface, the base forming a reservoir and a channel with an opening, the reservoir being in electrical or optical communication with the measurement device, the test sensor having a chemical reagent capable of reacting with an analyte in a biological fluid sample;

    receiving the biological fluid sample in the opening of the reservoir, the biological fluid sample flowing through the channel to fill at least in part the reservoir of the test sensor, the biological fluid sample including the analyte, the analyte in the biological fluid sample reacting in a chemical reaction with the chemical reagent in the reservoir;

    in response to the chemical reaction in the reservoir, generating an input signal from the signal generator for excitation of a chemical reaction product during an excitation period, the input signal including at least one excitation having a time period with an end-point;

    transmitting the input signal by the sensor interface to the sample interface for applying the input signal to the biological fluid sample;

    in response to the input signal and the concentration of the analyte in the biological fluid sample, generating, by the processor, one or more output signals from the test sensor;

    segmenting, by the processor, the one or more output signals during the excitation period into at least two segments with a regular or irregular segmenting interval, each segment including point readings obtained before the end-point of the input signal during the excitation period;

    converting, by the processor, the at least two segments into at least two signal processing parameters, wherein the signal processing parameters describe a portion of a total error in the one or more output signals;

    determining, by the processor, a segmented signal processing function from the signal processing parameters;

    using, by the processor, a predetermined reference correlation to relate the one or more output signals to a plurality of known sample analyte concentrations;

    in response to the predetermined reference correlation, using, by the processor, a conversion function to convert the one or more output signals into one known sample analyte concentration of the plurality of known sample analyte concentrations;

    determining, by the processor, a compensated value from the one or more output signals in response to the conversion function and the segmented signal processing function;

    determining, by the processor, the analyte concentration in the biological fluid sample from the compensated value of the one or more output signals; and

    outputting, by the processor, the analyte concentration to one or more of a display, a remote receiver, or a storage medium.

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