Non-invasive measurement device and method for estimating local metabolic parameters

• US 10,653,347 B2
• Filed: 09/26/2014
• Issued: 05/19/2020
• Est. Priority Date: 09/30/2013
• Status: Active Grant

• Current Assignee: Vygon
• Original Assignee: APD Advanced Perfusion Diagnostics
• Inventors: Beute, Jan, Bonidal, Remi
• Primary Examiner(s): Winakur, Eric F
• Application Number:
  US15/025,663
• Publication Number:
  US 20160213293A1
• Time in Patent Office: 2,062 Days
• Field of Search: 600300-399
• CPC Class Codes: A61B 5/0075 by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy A61B5/0071 takes precedence
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/1455 using optical sensors, e.g. spectral photometrical oximeters
• CPC Class Codes: A61B 5/14551 for measuring blood gases
• CPC Class Codes: A61B 5/14552 Details of sensors specially adapted therefor
• CPC Class Codes: A61B 5/1495 Calibrating or testing of in-vivo probes
• CPC Class Codes: G01N 33/721 Haemoglobin
• CPC Class Codes: G01N 33/726 Devices

Abstract

A method for estimating a local metabolic parameter of an area of tissue of a patient. The method receives light intensities from the area of tissue in question for at least three different wavelengths selected according to the absorptive power of different types of haemoglobin, on the basis of the absorbancy values calculated using the light intensities measured for the three wavelengths. The method determines a oxyhaemoglobin concentration and a deoxyhaemoglobin concentration and estimates at least one local metabolic parameter on the basis of the calculated oxyhaemoglobin and deoxyhaemo-globin concentrations.

Claims

1. A method for estimation of at least one local metabolic parameter of a relevant tissue area of a patient, wherein the method comprises the following steps:

shifting a catheter over a surface of the relevant tissue area, an optical sensor of an acquisition device being disposed at a distal end of the catheter,

wherein said optical sensor is comprised of at least three diodes and a receiver, each diode emitting a light radiation at a defined wavelength different of the others diodes so that the optical sensor emits a light intensity for at least three different wavelengths comprised between 600 and 1000 nm, the at least three different wavelengths being selected as a function of absorptivity of oxyhemoglobin and deoxyhemoglobin, said receiver measuring light intensity for the at least three different wavelengths,

positioning said optical sensor, against the wall of the relevant tissue area,

emitting each light radiation by each diode of the optical sensor at each of the at least three different wavelengths,

receiving said light intensity having passed through the relevant tissue area, said light intensity being measured by the receiver for at the least three different wavelengths so as to determine received light intensities,

wherein the step of receiving said light intensity comprises a step of;

receiving, a plurality of measured light intensities at different instants of a cardiac cycle for each of the at least three different wavelengths,

generating curves of said received light intensities over several cardiac cycles,

selecting at least one instant of the cardiac cycle of each plurality of measured light intensities so as to determine each selected light intensity for each wavelength,

calculating absorbance values from each selected light intensity for the at least three different three wavelengths,

determining a concentration of oxyhemoglobin and a concentration of deoxyhemoglobin from the absorbance values calculated for the at least three different three wavelengths, and

estimating at least one local metabolic parameter of the relevant tissue area of the patient from said concentrations of oxyhemoglobin and said concentration of deoxyhemoglobin,

wherein the step of estimating comprises;

estimating oxygen consumption in the relevant tissue area from said concentrations of oxyhemoglobin and said concentration of deoxyhemoglobin in the total blood and in the venous blood,

wherein the step of selecting comprises;

detecting at least one of a maxima and a minima in the curves of said received light intensities at the at least three wavelengths,

wherein, from all the measured light intensities of each wavelength, a light intensity for which an amount of arterial blood is minimum in the relevant tissue area such that the determined concentrations are representative of concentration of oxyhemoglobin and deoxyhemoglobin in the venous blood, and

wherein, from all the measured light intensities, light intensities for which the amount of arterial blood is maximum in the relevant tissue area such that the determined concentrations are representative of concentration of oxyhemoglobin and deoxyhemoglobin in the total blood.

2. The method according to claim 1, wherein the the step of estimating oxygen consumption comprises the step of estimating a rate of oxygenation of the relevant tissue area from said concentration of oxyhemoglobin and said concentration of deoxyhemoglobin.

3. The method according to claim 1, which further comprises an additional step of obtaining denoised values corresponding to the results of a mathematical function applied to a plurality of absorbance values for each of at least the three wavelengths, the determination step consisting of calculating the concentrations of oxyhemoglobin and deoxyhemoglobin from the denoised values, wherein the step of obtaining denoised value occurring between the selection step and the determination step.

4. The method according to claim 1, wherein the reception step comprises the reception of measured light intensities for:

a first wavelength at which the light absorption of deoxyhemoglobin is greater than the light absorption of oxyhemoglobin,

a second wavelength at which the light absorption of oxyhemoglobin is greater than the light absorption of deoxyhemoglobin, and

a third wavelength corresponding to an isobestic point at which the light absorptions of oxyhemoglobin and of deoxyhemoglobin are equal.

5. The method according to claim 4, wherein the first wavelength is comprised between 600 and 700 nm.

6. The method according to claim 5, wherein the first wavelength is equal to 660 nm.

7. The method according to claim 4, wherein the second wavelength is comprised between 900 and 1000 nm.

8. The method according to claim 7, wherein, wherein the second wavelength is equal to 906 nm.

9. The method according to claim 4, wherein the third wavelength is comprised between 796 nm and 810 nm.

10. The method according to claim 9, wherein the third wavelength is equal to 810 nm.

11. The method according to claim 1, wherein the reception step comprises the reception of measured light intensities for a fourth wavelength comprised between 700 nm and 800 nm, the calculation step consisting of calculating the absorbance values from values of measured light intensities for the four wavelengths.

12. The method according to claim 11, wherein the fourth wavelength is equal to 750 nm.

13. The method according to claim 1, wherein the determination step comprises resolution of a system of equations linking a set of unknowns comprising:

the concentration of oxyhemoglobin,

the concentration of deoxyhemoglobin, and

a tissue absorption coefficient,

said equations using absorbance values as a function of molar absorptivity values in accordance with the Beer-Lambert law using at least three wavelengths.

14. The method according to claim 13, wherein the determination step comprises resolution of a following system:

15. The method according to claim 1, wherein the determination step comprises resolution of a system of equations by a regularised optimisation method.