Two-dimensional materials and uses thereof

• US 10,653,824 B2
• Filed: 04/14/2016
• Issued: 05/19/2020
• Est. Priority Date: 05/25/2012
• Status: Active Grant

• Current Assignee: Lockheed Martin Corporation (Martin Marietta Corporation)
• Original Assignee: Lockheed Martin Corporation (Martin Marietta Corporation)
• Inventors: Bedworth, Peter V., Bullock, Steven Edward, Simon, Sarah M., Sinton, Steven W., Stetson, Jr., John B., Swett, Jacob L., Heise, Scott E.
• Primary Examiner(s): Fortuna, Ana M
• Application Number:
  US15/099,588
• Publication Number:
  US 20160339160A1
• Time in Patent Office: 1,496 Days
• Field of Search: None
• CPC Class Codes: A61M 1/1621 Constructional aspects thereof semi-permeable membranes for separation processes characterised by their properties B01D69/00; semi permeable membranes characterised by their material B01D71/00
• CPC Class Codes: A61M 1/1623 Disposition or location of membranes relative to fluids
• CPC Class Codes: A61M 1/1631 having non-tubular membranes, e.g. sheets
• CPC Class Codes: A61M 2207/00 Methods of manufacture, assembly or production
• CPC Class Codes: B01D 61/243 Dialysis
• CPC Class Codes: B01D 67/0062 by micromachining techniques, e.g. using masking and etching steps, photolithography
• CPC Class Codes: B01D 67/0069 by deposition from the liquid phase, e.g. electrochemical deposition B01D67/0046 takes precedence
• CPC Class Codes: B01D 67/0072 by deposition from the gaseous phase, e.g. sputtering, CVD, PVD
• CPC Class Codes: B01D 69/10 Supported membranes; Membrane supports
• CPC Class Codes: B01D 69/107 Organic support material
• CPC Class Codes: B01D 71/021 Carbon
• CPC Class Codes: B01D 71/0211 Graphene or derivates thereof
• CPC Class Codes: H01J 2237/3174 Etching microareas
• CPC Class Codes: H01J 37/3056 for microworking, e.g. etching of gratings, trimming of electrical components trimming of resistors H01C17/22

Abstract

Various systems and methods relating to two-dimensional materials such as graphene. A membrane include a cross-linked graphene platelet polymer that includes a plurality of cross-linked graphene platelets. The cross-linked graphene platelets include a graphene portion and a cross-linking portion. The cross-linking portion contains a 4 to 10 atom link. The cross-linked graphene platelet polymer is produced by reaction of an epoxide functionalized graphene platelet and a (meth)acrylate or (meth)acrylamide functionalized cross-linker.

Claims

1. A process for forming a blood filtration device, comprising:

exposing a multilayered material to ions provided by an ion source, the multilayered material comprising a first layer comprising a two-dimensional first material and a second layer of a second material in contact with the first layer, wherein the ions have an ion energy ranging from 1.0 keV to 10 keV, and a flux from 0.1 nA/mm² to 100 nA/mm²; and

producing a perforated two-dimensional material by producing a plurality of through-holes in the two-dimensional first material by interacting the ions with the two-dimensional first material and with the second material;

forming at least two of a composite membrane comprising a porous substrate having a plurality of pores and a sheet of the perforated two-dimensional material disposed on a surface of the porous substrate and defining a top surface of the composite membrane, wherein the sheet of the perforated two-dimensional material covers at least a portion of the plurality of pores of the porous substrate and wherein at least one pore of the substrate is not covered by the sheet of the perforated two-dimensional material;

introducing one or more occluding moieties at least partially into the at least one uncovered pore to occlude the at least one uncovered pore;

incorporating at least two of the composite membranes to form the blood filtration device;

forming a cross-linked graphene platelet polymer membrane by reacting an epoxide-functionalized graphene platelet with a (meth)acrylate- or (meth)acrylamide-functionalized cross-linker; and

incorporating the cross-linked graphene platelet polymer membrane, having a plurality of cross-linked graphene platelets, into the blood filtration device,

wherein the plurality of cross-linked graphene platelets have a graphene portion and a cross-linking portion, the cross-linking portion containing a 4- to 10-atom link.

2. The method of claim 1, wherein the perforated two-dimensional material is graphene-based material.

3. The method of claim 2, wherein the graphene-based material is single-layer graphene.

4. The method of claim 2, wherein the perforated two-dimensional material is graphene oxide.

5. The method of claim 1, wherein the one or more occluding moieties are particles sized for at least partial introduction into the at least one uncovered pore, but which cannot exit the at least one uncovered pore.

6. The method of claim 5, wherein the particles are deformable or swellable.

7. The method of claim 5, further comprising:

applying pressure or energy to the particles after the particles are at least partially introduced into the at least uncovered pore,

wherein the particles are deformable.

8. The method of claim 7, wherein heat or light of a selected wavelength is applied to the particles.

9. The method of claim 7, wherein an electron or ion beam is applied to the particles.

10. The method of claim 1, wherein the at least two composite membranes are a hemodialysis membrane.

11. A method of removing contaminants from blood of a patient, comprising:

exposing the blood to the hemodialysis membrane of the blood filtration device formed by the method of claim 10;

removing at least one contaminant from the blood with the hemodialysis membrane; and

recirculating purified blood to the patient.

12. The method of claim 1, wherein the sheet of the perforated two-dimensional material is primed, activated, or functionalized to bind or react with the occluding moieties.

13. The method of claim 1, wherein the one or more occluding moieties are selected from the group consisting of oligomers, uncured polymers, uncross-linked polymers, hydrogels, proteins, zeolites, metal-organic framework materials, or thin film solution membranes.

14. The method of claim 1, wherein the one or more occluding moieties are selected from the group consisting of polyhedral oligomeric silsesquioxanes, fullerenes, dendrites, dextran, micelles or other lipid aggregates, micro-gel particles, silica particles covered with polyethylene glycol, and hydroxycellulose.

15. The method of claim 1, wherein the one or more occluding moieties are fluorescently tagged.