Analyte sensing biointerface

• US 10,667,729 B2
• Filed: 06/27/2019
• Issued: 06/02/2020
• Est. Priority Date: 04/15/2005
• Status: Active Grant

• Current Assignee: DexCom Incorporated
• Original Assignee: DexCom Incorporated
• Inventors: Simpson, Peter C., Brauker, James H.
• Primary Examiner(s): Jang, Christian
• Application Number:
  US16/455,468
• Publication Number:
  US 20190313952A1
• Time in Patent Office: 341 Days
• CPC Class Codes: A61B 5/0031 Implanted circuitry
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/1486 using enzyme electrodes, e.g. with immobilised oxidase
• CPC Class Codes: A61B 5/14865 invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
• CPC Class Codes: B33Y 80/00 Products made by additive manufacturing
• CPC Class Codes: C12Q 1/001 Enzyme electrodes
• CPC Class Codes: C12Q 1/006 for glucose

Abstract

Disclosed herein is an analyte sensing biointerface that comprises a sensing electrode incorporated within a non-conductive matrix comprising a plurality of passageways extending through the matrix to the sensing electrode. Also disclosed herein are methods of manufacturing a sensing biointerface and methods of detecting an analyte within tissue of a host using an analyte sensing biointerface.

Claims

1. A transcutaneous continuous glucose sensor system, comprising:

a substantially planar sensor, the sensor comprising;

a first non-conductive layer;

a first conductive layer associated with a first electrode, wherein the first conductive layer is disposed at least in part over the first non-conductive layer;

a second non-conductive layer disposed at least in part over the first conductive layer;

a second conductive layer associated with a second electrode, wherein the second conductive layer is disposed at least in part over the second non-conductive layer;

a third non-conductive layer disposed at least in part over the second conductive layer;

a third conductive layer associated with a third electrode, wherein the third conductive layer is disposed at least in part over the third non-conductive layer; and

a membrane disposed over at least a portion of a working electrode;

wherein at least one of the first electrode, the second electrode, or the third electrode is the working electrode, and wherein the working electrode is configured to measure a signal indicative of a glucose concentration.

2. The transcutaneous continuous glucose sensor system of claim 1, wherein the membrane comprises an enzyme.

3. The transcutaneous continuous glucose sensor system of claim 2, wherein the membrane further comprises a resistance domain disposed over the enzyme.

4. The transcutaneous continuous glucose sensor system of claim 1, wherein the membrane comprises a bioactive agent.

5. The transcutaneous continuous glucose sensor system of claim 1, wherein the membrane is substantially planar.

6. The transcutaneous continuous glucose sensor system of claim 1, wherein at least a portion of the first non-conductive layer is in physical contact with at least a portion of the first conductive layer.

7. The transcutaneous continuous glucose sensor system of claim 1, further comprising sensor electronics configured to electrically couple to the working electrode.

8. The transcutaneous continuous glucose sensor system of claim 1, wherein at least a portion of the first non-conductive layer is physically separate from the first conductive layer.

9. The transcutaneous continuous glucose sensor system of claim 1, further comprising sensor electronics having one or more contacts for operably connecting to the working electrode.