Vaginal inserted estradiol pharmaceutical compositions and methods

  • US 10,668,082 B2
  • Filed: 05/09/2018
  • Issued: 06/02/2020
  • Est. Priority Date: 10/22/2014
  • Status: Active Grant
First Claim
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1. A method of treating vulvovaginal atrophy (VVA), comprising vaginally administering to a subject in need thereof a liquid pharmaceutical composition comprising estradiol at a dosage of 4 mcg, wherein the composition has a viscosity in the range of about 50 cP to about 1000 cP at 25°

  • C., and increasing the dosage of estradiol if the subject does not exhibit an improvement in a clinical response for VVA.

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