Anti-PD-L1 antibodies and diagnostic uses thereof

  • US 10,689,445 B2
  • Filed: 10/06/2017
  • Issued: 06/23/2020
  • Est. Priority Date: 07/11/2014
  • Status: Active Grant
First Claim
Patent Images

1. An isolated antibody that specifically binds PD-L1, wherein the antibody comprises a heavy chain variable domain (VH) and a light chain variable domain (VL) that comprises the following hypervariable regions (HVRs):

  • (a) an HVR-H1 comprising the amino acid sequence of SNGLT (SEQ ID NO;

         2);

    (b) an HVR-H2 comprising the amino acid sequence of TINKDASAYYASWAKG (SEQ ID NO;

         3);

    (c) an HVR-H3 comprising the amino acid sequence of IAFKTGTSI (SEQ ID NO;

    4);

    (d) an HVR-L1 comprising the amino acid sequence of QASESVYSNNYLS (SEQ ID NO;

         9);

    (e) an HVR-L2 comprising the amino acid sequence of LASTLAS (SEQ ID NO;

         10); and

    (f) an HVR-L3 comprising the amino acid sequence of IGGKSSSTDGNA (SEQ ID NO;

         11).

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