Assays for determining levels of plasma protease C1 inhibitor

  • US 10,690,670 B2
  • Filed: 01/17/2014
  • Issued: 06/23/2020
  • Est. Priority Date: 01/20/2013
  • Status: Active Grant
First Claim
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1. A method, comprising:

  • contacting a sample containing plasma protease C1 inhibitor (C1-INH) with a capture reagent, andmeasuring a level of the C1-INH in the sample that binds to the capture reagent;

    wherein the capture reagent comprises;

    i) an active form of Factor XII,ii) an active form of plasma kallikrein, oriii) a combination of i) and ii);

    wherein the active form of plasma kallikrein retains protease activity of a naturally occurring plasma kallikrein and the active form of Factor XII retains blood coagulation activity of a naturally occurring Factor XII.

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