Activity-dependent multi-mode physiological sensor

• US 10,695,004 B2
• Filed: 06/05/2018
• Issued: 06/30/2020
• Est. Priority Date: 12/02/2011
• Status: Active Grant

• Current Assignee: Lumiradx UK Ltd
• Original Assignee: Lumiradx UK Ltd
• Inventors: Gaudet, Paul J., Quinlan, III, Thomas J., Zhang, Jerry, Ohlenbusch, Norbert, Blackadar, Thomas P., Monahan, David P.
• Primary Examiner(s): Hulbert, Amanda K
• Assistant Examiner(s): Edwards, Philip C
• Application Number:
  US16/000,529
• Publication Number:
  US 20180279901A1
• Time in Patent Office: 756 Days
• Field of Search: 600509
• CPC Class Codes: A61B 2560/0412 Low-profile patch shaped housings
• CPC Class Codes: A61B 2562/0219 Inertial sensors, e.g. accelerometers, gyroscopes, tilt switches
• CPC Class Codes: A61B 5/1118 Determining activity level
• CPC Class Codes: A61B 5/259 using conductive adhesive means, e.g. gels
• CPC Class Codes: A61B 5/28 for electrocardiography [ECG]
• CPC Class Codes: A61B 5/7214 using signal cancellation, e.g. based on input of two identical physiological sensors spaced apart, or based on two signals derived from the same sensor, for different optical wavelengths
• CPC Class Codes: G01C 22/006 Pedometers
• CPC Class Codes: G16H 10/60 for patient-specific data, e.g. for electronic patient records
• CPC Class Codes: G16H 20/40 relating to mechanical, radiation or invasive therapies, e.g. surgery, laser therapy, dialysis or acupuncture
• CPC Class Codes: G16H 40/67 for remote operation
• CPC Class Codes: G16H 50/20 for computer-aided diagnosis, e.g. based on medical expert systems

Abstract

Disclosed are systems and methods for using one or more light sources and associated photodetectors to determine different physiological parameters of a subject based on the subject'"'"'s activity state. A processor may, for example, be configured to determine, based at least in part on data received from an accelerometer at a first time, that a first physiological parameter of the subject is to be determined, to cause the light source(s) to operate in a first manner and process signals from the photodetector(s) to determine the first physiological parameter, to determine, based at least in part on data received from the accelerometer at a second time, that a second physiological parameter of the subject is to be determined, and to cause the light source(s) to operate in a second manner and process signals from the photodetector(s) to determine the second physiological parameter.

Claims

1. A system that is configured to be supported by a subject, the system comprising:

a processor;

an accelerometer;

at least one light source configured to interrogate a region of the subject; and

at least one photodetector configured to receive radiation from the at least one light source which is reflected from or transmitted through the region of the subject;

wherein the processor is configured to;

determine, based at least in part on data received from the accelerometer at a first time, that a first physiological parameter of the subject is to be determined,

in response to determining that the first physiological parameter is to be determined, cause the at least one light source to operate and process signals from the at least one photodetector to determine the first physiological parameter,

determine, based at least in part on data received from the accelerometer at a second time, that a second physiological parameter of the subject, which is different than the first physiological parameter, is to be determined, and

in response to determining that the second physiological parameter is to be determined, cause the at least one light source to operate and process signals from the at least one photodetector to determine the second physiological parameter.

2. The system of claim 1, wherein the processor is further configured to:

cause the at least one light source to operate in a first manner to determine the first physiological parameter; and

cause the at least one light source to operate in a second manner, which is different than the first manner, to determine the second physiological parameter.

3. The system of claim 1, wherein the first physiological parameter comprises a blood oxygenation level of the subject.

4. The system of claim 3, wherein the second physiological parameter comprises a heart rate of the subject.

5. The system of claim 3, wherein the second physiological parameter comprises a blood glucose level of the subject.

6. The system of claim 3, wherein the second physiological parameter comprises at least one feature of a plethysmography waveform.

7. The system of claim 2, wherein the first physiological parameter comprises a heart rate of the subject.

8. The system of claim 7, wherein the second physiological parameter comprises a blood glucose level of the subject.

9. The system of claim 7, wherein the second physiological parameter comprises at least one feature of a plethysmography waveform.

10. The system of claim 1, wherein:

the first physiological parameter comprises a blood glucose level of the subject, and the second physiological parameter comprises at least one feature of a plethysmography waveform.

11. A method, comprising:

interrogating a region of a subject with light emitted from at least one light source;

receiving, with at least one photodetector, radiation from the at least one light source which is reflected from or transmitted through the region of the subject; and

using a processor to;

determine, based at least in part on data received from an accelerometer at a first time, that a first physiological parameter of the subject is to be determined,

in response to determining that the first physiological parameter is to be determined, cause the at least one light source to operate and process signals from the at least one photodetector to determine the first physiological parameter,

determine, based at least in part on data received from the accelerometer at a second time, that a second physiological parameter of the subject, which is different than the first physiological parameter, is to be determined, and

in response to determining that the second physiological parameter is to be determined, cause the at least one light source to operate and process signals from the at least one photodetector to determine the second physiological parameter.

12. The method of claim 11, wherein:

using the processor to cause the at least one light source to operate to determine the first physiological parameter further comprises using the processor to cause the at least one light source to operate in a first manner; and

using the processor to cause the at least one light source to operate to determine the second physiological parameter further comprises using the processor to cause the at least one light source to operate in a second manner, which is different than the first manner, to determine the second physiological parameter.

13. The method of claim 11, wherein the first physiological parameter comprises a blood oxygenation level of the subject.

14. The method of claim 13, wherein the second physiological parameter comprises a heart rate of the subject.

15. The method of claim 13, wherein the second physiological parameter comprises a blood glucose level of the subject.

16. The method of claim 13, wherein the second physiological parameter comprises at least one feature of a plethysmography waveform.

17. The method of claim 11, wherein the first physiological parameter comprises a heart rate of the subject.

18. The method of claim 17, wherein the second physiological parameter comprises a blood glucose level of the subject.

19. The method of claim 17, wherein the second physiological parameter comprises at least one feature of a plethysmography waveform.

20. The method of claim 11, wherein:

the first physiological parameter comprises a blood glucose level of the subject; and

the second physiological parameter comprises at least one feature of a plethysmography waveform.