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Iterative probabilistic parameter estimation apparatus and method of use therefor

  • US 10,699,206 B2
  • Filed: 02/27/2018
  • Issued: 06/30/2020
  • Est. Priority Date: 04/22/2009
  • Status: Active Grant
First Claim
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1. An apparatus for estimation of a biomedical state of a body having a cardiovascular system, comprising:

  • a biomedical device comprising;

    a pulse oximeter;

    an electrocardiogram device;

    an output display screen; and

    a digital signal processor integrated into said biomedical device, said biomedical device configured to;

    use a dynamic state-space model, implemented with a probability distribution function representative of a physiological description of the cardiovascular system, to provide a prior probability distribution function;

    receive sensor data input from at least two data sources, wherein the sensor data from said at least two data sources comprises;

    first output from said pulse oximeter, said pulse oximeter configured to monitor a first sub-system of the cardiovascular system, said pulse oximeter used to determine a first parameter comprising a first unit of measure; and

    second output from said electrocardiogram device, said electrocardiogram device configured to monitor a second sub-system of the cardiovascular system, said electrocardiogram device used to determine a second parameter comprising a second unit of measure, said first unit of measure distinct from said second unit of measure;

    iteratively use a probabilistic updater to integrate the sensor data as a fused data set and generate a posterior probability distribution function using all of;

    (1) the fused data set;

    (2) an application of Bayesian probability; and

    (3) said prior probability distribution function; and

    generate an output of a biomedical state using said posterior probability function to an output display screen,wherein said output of a biomedical state comprises an indirect parameter having a third unit of measure distinct from both said first unit of measure and said second unit of measure, said indirect parameter calculated using both said first output and said second output,wherein said indirect parameter comprises at least one of;

    a filling rate of the heart; and

    a measure of contractility of the heart; and

    at least one of said pulse oximeter and said electrocardiogram device comprise an element of a medical rack system.

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