Polymorphous forms of rifaximin, processes for their production and use thereof in the medicinal preparations

  • US 10,703,763 B2
  • Filed: 03/04/2019
  • Issued: 07/07/2020
  • Est. Priority Date: 03/03/2005
  • Status: Active Grant
First Claim
Patent Images

1. A method of treating bacterial activity in the gastrointestinal tract of a subject, the method comprising:

  • orally administering to the subject a pharmaceutical composition comprising a therapeutically effective amount of rifaximin δ

    together with a pharmaceutically acceptable excipient selected from the group consisting of diluting, binding, lubricating, disintegrating, colouring, flavouring and sweetening agents,wherein rifaximin δ

    has a powder X-ray diffractogram showing peaks at values of the diffraction angles 2θ

    of about 5.7°

    ±

    0.2, 6.7°

    ±

    0.2, 7.1°

    ±

    0.2, 8.0°

    ±

    0.2, 8.7°

    ±

    0.2, 10.4°

    ±

    0.2, 10.8°

    ±

    0.2, 11.3°

    ±

    0.2, 12.1°

    ±

    0.2, 17.0°

    ±

    0.2, 17.3°

    ±

    0.2, 17.5°

    ±

    0.2, 18.5°

    ±

    0.2, 18.8°

    ±

    0.2, 19.1°

    ±

    0.2, 21.0°

    ±

    0.2, 21.5°

    ±

    0.2.

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