System and methods for processing analyte sensor data for sensor calibration

  • US 10,716,498 B2
  • Filed: 11/21/2019
  • Issued: 07/21/2020
  • Est. Priority Date: 03/10/2005
  • Status: Active Grant
First Claim
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1. A method of making one or more glucose monitoring systems, the method comprising:

  • manufacturing one or more transcutaneous electrochemical glucose sensors, each transcutaneous electrochemical glucose sensor having an in vivo portion and an ex vivo portion;

    examining an in vitro signal response of at least one of the one or more transcutaneous electrochemical glucose sensors for each of a plurality of known glucose concentrations;

    calculating an in vitro sensitivity for at least one of the one or more transcutaneous electrochemical glucose sensors, based on the in vitro signal responses;

    predicting an in vivo sensitivity for at least one of the one or more transcutaneous electrochemical glucose sensors based at least in part on (1) the calculated in vitro sensitivity and (2) a relationship between in vivo responses and in vitro data empirically established in at least one previously performed clinical study;

    storing the predicted in vivo sensitivity in a memory; and

    configuring one or more processors to calibrate data generated by at least one of the one or more transcutaneous electrochemical glucose sensors using the predicted in vivo sensitivity without reliance on any manual calibrations by a user of at least one of the one or more glucose monitoring systems following insertion of at least a portion of the at least one of the one or more transcutaneous electrochemical glucose sensors.

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