Pharmaceutical spray composition comprising a vitamin D analogue and a corticosteroid

  • US 10,716,799 B2
  • Filed: 08/28/2019
  • Issued: 07/21/2020
  • Est. Priority Date: 06/11/2010
  • Status: Active Grant
First Claim
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1. A sprayable, substantially anhydrous topical composition comprisingcalcipotriol or calcipotriol monohydrate,betamethasone dipropionate,a pharmaceutically acceptable propellant, present in amount between 45-95% w/w of the total composition,a pharmaceutically acceptable lipid carrier, present in an amount between 5-55% w/w of the total composition, anda pharmaceutically acceptable antioxidant,wherein the composition does not include propylene glycol,wherein visible crystals of the calcipotriol or calcipotriol monohydrate or the betamethasone dipropionate are not observed, as determined by polarized light microscopy, after storage of the composition for 12 months at about 25°

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