Closed-loop glucose and/or insulin control system

• US 10,722,170 B2
• Filed: 06/01/2017
• Issued: 07/28/2020
• Est. Priority Date: 06/17/2009
• Status: Active Grant

• Current Assignee: Medtronic Minimed Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Minimed Incorporated (Medtronic Plc)
• Inventors: Cantwell, Martin, Clark, H. Bud, Steil, Garry M.
• Primary Examiner(s): Bosworth, Kami A
• Assistant Examiner(s): Swanson, Leah J
• Application Number:
  US15/610,921
• Publication Number:
  US 20170325736A1
• Time in Patent Office: 1,153 Days
• CPC Class Codes: A61B 2560/0276 Determining malfunction
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/4839 combined with drug delivery
• CPC Class Codes: A61M 2005/14208 with a programmable infusion control system, characterised by the infusion program
• CPC Class Codes: A61M 2005/1581 Right-angle needle-type devices
• CPC Class Codes: A61M 2205/3569 sublocal, e.g. between console and disposable
• CPC Class Codes: A61M 2205/3592 using telemetric means, e.g. radio or optical transmission
• CPC Class Codes: A61M 2230/201 Glucose concentration
• CPC Class Codes: A61M 5/14244 adapted to be carried by the patient, e.g. portable on the body
• CPC Class Codes: A61M 5/1723 using feedback of body parameters, e.g. blood-sugar, pressure measurement of body parameters A61B5/00

Abstract

A method and/or system may be provided for determining a suggested change in a recommended therapy for a patient based, at least in part, on sensor measurements, and generating an alert to an attendant in a hospital environment upon detection of the suggested change. A method and/or system may also be provided to automatically determine a maximum interval to alert an attendant following receipt of a measurement at an operator interface. A method and/or system may also be provided to blood-glucose sensor calibration.

Claims

1. A method comprising:

receiving a signal representative of a measurement value entered at an operator interface;

receiving signals representative of blood glucose sensor measurements obtained subsequent to receipt of the signal representative of the measurement value; and

executing instructions on a special purpose computing apparatus to;

compute one or more commands to a delivery system based, at least in part, on the received signals representative of the blood glucose sensor measurements; and

determine a maximum duration following entry of the measurement value until initiation of an alert to an operator based, at least in part, on at least one of the one or more computed commands.

2. The method of claim 1, wherein the maximum duration to be based, at least in part, on the measurement value.

3. The method of claim 1, and further comprising executing the instructions on the special purpose computing apparatus to determine the maximum duration based, at least in part, on a signal representative of a measured rate of change in blood glucose of a patient.

4. The method of claim 1,

wherein the one or more computed command to the delivery system comprise one or more proportional, plus integral, plus derivative (PID) commands based, at least in part, on the signals representative of the blood glucose sensor measurements.

5. The method of claim 1, and further comprising executing the instructions on the special purpose computing apparatus to:

determine the maximum duration based, at least in part, on whether a glucose bolus was infused to a patient contemporaneously with receipt of the signal representative of the measurement value.

6. The method of claim 1, and further comprising further executing the instructions on the special purpose computing apparatus to determine the maximum duration based, at least in part, on one or more signals representative of a measured rate of change in blood glucose of a patient.

7. The method of claim 1, wherein the entered measurement value to comprise a blood glucose sample measurement value.

8. The method of claim 1, and further comprising generating the alert as a callback alert message to an attendant.

9. The method of claim 8, and further comprising shortening the maximum duration based, at least in part, on a forecasted blood glucose level, proximity of a blood glucose level to limits of a target blood glucose range or proximity of the blood glucose level to hypoglycemic or hyperglycemic warning limits, or a combination thereof.

10. An apparatus comprising:

an operator interface to receive entry of an input value representative of a measurement value;

a blood glucose sensor to provide signals representative of blood glucose sensor measurements obtained from a patient;

and

one or more processors to;

compute one or more commands to a delivery system based, at least in part, on signals representative of blood glucose sensor measurements obtained from the blood glucose sensor subsequent to entry of the input value; and

determine a maximum duration following entry of the measured value until initiation of an alert to an operator based, at least in part, on at least one of the one or more computed commands.

11. The apparatus of claim 10, wherein the maximum duration to be determined based, at least in part, on the measurement value.

12. The apparatus of claim 10, wherein the one or more processors to be further adapted to determine the maximum duration based, at least in part, on a signal representative of a measured rate of change in blood glucose of the patient.

13. The apparatus of claim 10,

wherein the computed one or more commands comprise one or more proportional, plus integral, plus derivative (PID) commands based, at least in part, on the signals representative of blood glucose sensor measurements.

14. The apparatus of claim 10, wherein the one or more processors to be further adapted to:

determine the maximum duration further based, at least in part, on whether a glucose bolus was infused to a patient contemporaneously with entry of the input value representative of the measurement value.

15. The apparatus of claim 10, wherein the one or more processors to be further adapted to determine the maximum duration further based, at least in part, on one or more signals representative of a measured rate of change in blood glucose of a patient.

16. The apparatus of claim 10, wherein the measurement value to comprise a blood glucose sample measurement value.

17. The apparatus of claim 10, wherein the one or more processors to be further adapted to generate a callback alert message to an attendant at an instance prior to expiration of the maximum duration.

18. The apparatus of claim 10, wherein the one or more processors to be further adapted to determine an instance prior to expiration of the maximum duration based, at least in part, on a forecasted blood glucose level, proximity of a blood glucose level to limits of a target blood glucose range or proximity of the blood glucose level to hypoglycemic or hyperglycemic warning limits, or a combination thereof.

19. The apparatus of claim 10, wherein the maximum duration to be further based, at least in part, on an indication of a predetermined predisposition for hypoglycemia in a patient.

20. The apparatus of claim 19, wherein the one or more processors to be further adapted to obtain the indication of the predetermined predisposition for hypoglycemia in the patient from one or more entries to the operator interface or an indication received from a remote database to be accessible by the apparatus over an electronic data communication network, or a combination thereof.