Topical compositions

• US 10,722,436 B2
• Filed: 08/10/2016
• Issued: 07/28/2020
• Est. Priority Date: 08/10/2015
• Status: Active Grant

• Current Assignee: Mary Kay Incorporated (Mary Kay Holding Corporation)
• Original Assignee: Mary Kay Incorporated (Mary Kay Holding Corporation)
• Inventors: Carle, Tiffany, Frushour, Michael, Gan, David, Kalahasti, Geetha, Jacoby, Patricia
• Primary Examiner(s): Ghali, Isis A
• Application Number:
  US15/233,451
• Publication Number:
  US 20170042778A1
• Time in Patent Office: 1,448 Days
• Field of Search: None
• CPC Class Codes: A61K 2800/782 Enzyme inhibitors; Enzyme antagonists
• CPC Class Codes: A61K 8/11 Encapsulated compositions
• CPC Class Codes: A61K 8/347 Phenols
• CPC Class Codes: A61K 8/606 Nucleosides; Nucleotides; Nucleic acids
• CPC Class Codes: A61K 8/64 Proteins; Peptides; Derivatives or degradation products thereof
• CPC Class Codes: A61K 8/675 Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde tocopheryl nicotinate A61K8/678
• CPC Class Codes: A61K 8/97 from algae, fungi, lichens or plants; from derivatives thereof
• CPC Class Codes: A61K 8/9706 Algae
• CPC Class Codes: A61K 8/9711 Phaeophycota or Phaeophyta [brown algae], e.g. Fucus
• CPC Class Codes: A61K 8/9789 Magnoliopsida [dicotyledons]
• CPC Class Codes: A61Q 17/04 Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
• CPC Class Codes: A61Q 19/02 for chemically bleaching or whitening the skin
• CPC Class Codes: A61Q 19/08 Anti-ageing preparations
• CPC Class Codes: A61Q 19/10 Washing or bathing preparations

Abstract

The present invention relates generally to methods and compositions useful for a topical composition comprising encapsulated resveratrol, oligopeptide-1, niacinamide, Opuntia ficus-indica extract, Prunus mume extract, algae extract, malachite extract, adenosine, and/or Opuntia tuna fruit extract.

Claims

1. A method of reducing oxidative damage of skin comprising applying to oxidant damaged skin a topical composition comprising encapsulated resveratrol, oligopeptide-1, niacinamide, and Prunus mume leaf aqueous extract, and optionally one or more of Opuntia tuna fruit extract, malachite extract, adenosine, algae extract, or Opuntia ficus-indica fruit extract, wherein the combination of encapsulated resveratrol, oligopeptide-1, and niacinamide reduces oxidative damage in the skin, and wherein the oligopeptide-1 comprises the sequence of caprooyl-Gly-His-Lys-Lys.

2. The method of claim 1, wherein further the oligopeptide-1 inhibits tyrosinase, increases production of elastin, stimulates collagen production and/or secretion, and/or inhibits TNF-α

;

niacinamide inhibits melanogenesis and Prunus mume leaf aqueous extract stimulates collagen production and/or secretion, increases laminin production, and/or increases antioxidant capacity of the composition; and

optionally Opuntia tuna fruit extract inhibits COX-1, inhibits COX-2, inhibits lipoxygenase, and/or inhibits TNF-α

;

malachite extract inhibits MMP1, inhibits COX-1, inhibits COX-2, inhibits lipoxygenase, and/or increases antioxidant capacity of the composition;

algae extract increases skin barrier integrity; and

/or Opuntia ficus-indica fruit extract inhibits COX-1, inhibits COX-2, inhibits lipoxygenase, and/or inhibits TNF-α

.

3. The method of claim 1, wherein the topical composition comprises:

0.00001 to 0.1% by weight of encapsulated resveratrol, 0.0000001 to 0.01% by weight of oligopeptide-1, 0.001 to 3% by weight of niacinamide, and 0.01 to 3% by weight of Prunus mume leaf aqueous extract; and

optionally one or more of 0.00001 to 0.01% by weight of Opuntia tuna fruit extract, 0.00001 to 0.1% by weight of malachite extract, 0.001 to 1% by weight of adenosine, 0.001 to 1% by weight of algae extract, or 0.001 to 3% by weight of Opuntia ficus-indica fruit extract.

4. The method of claim 1, wherein the topical composition is applied to the skin daily.

5. The method of claim 2, wherein:

the oligopeptide-1 inhibits tyrosinase, increases production of elastin, stimulates collagen production and/or secretion, and/or inhibits TNF-α

;

niacinamide inhibits melanogenesis; and

Prunus mume leaf extract stimulates collagen production and/or secretion, increases laminin production, and/or increases antioxidant capacity of the composition, and

optionally wherein Opuntia tuna fruit extract inhibits COX-1, inhibits COX-2, inhibits lipoxygenase, and/or inhibits TNF-α

;

malachite extract inhibits MIMP1, inhibits COX-1, inhibits COX-2, inhibits lipoxygenase, and/or increases antioxidant capacity of the composition;

algae extract increases skin barrier integrity; and

/or Opuntia ficus-indica fruit extract inhibits COX-1, inhibits COX-2, inhibits lipoxygenase, and/or inhibits TNF-α

.

6. The method of claim 2, wherein:

the oligopeptide-1 inhibits tyrosinase, increases production of elastin, stimulates collagen production and/or secretion, and inhibits TNF-α

;

niacinamide inhibits melanogenesis; and

Prunus mume leaf extract stimulates collagen production and/or secretion, increases laminin production, and increases antioxidant capacity of the composition; and

optionally wherein Opuntia tuna fruit extract inhibits COX-1, inhibits COX-2, inhibits lipoxygenase, and inhibits TNF-α

;

malachite extract inhibits MIMP1, inhibits COX-1, inhibits COX-2, inhibits lipoxygenase, and increases antioxidant capacity of the composition;

algae extract increases skin barrier integrity; and

/or Opuntia ficus-indica fruit extract inhibits COX-1, inhibits COX-2, inhibits lipoxygenase, and inhibits TNF-α

.

7. The method of claim 2, wherein the topical composition further comprises water, hydroxyacetophenone, and tocopheryl acetate.

8. The method of claim 7, wherein the topical composition comprises:

0.00001 to 0.1% by weight of encapsulated resveratrol, 0.0000001 to 0.01% by weight of oligopeptide-1, 0.001 to 3% by weight of niacinamide, 0.01 to 3% by weight of Prunus mume leaf aqueous extract, 25 to 98% by weight of water, 0.01 to 3% by weight of hydroxyacetophenone, and 0.001 to 1% by weight of tocopheryl acetate,

and optionally one or more of 0.00001 to 0.01% by weight of Opuntia tuna fruit extract, 0.00001 to 0.1% by weight of malachite extract, 0.001 to 1% by weight of adenosine, 0.001 to 1% by weight of algae extract, or 0.001 to 3% by weight of Opuntia ficus-indica fruit extract.

9. The method of claim 2, wherein the topical composition further comprises isohexadecane, dimethicone, aluminum starch octenyl succinate, and caprylic/capric triglyceride.

10. The method of claim 9, wherein the topical composition comprises:

0.00001 to 0.1% by weight of encapsulated resveratrol, 0.0000001 to 0.01% by weight of oligopeptide-1, 0.001 to 3% by weight of niacinamide, 0.01 to 3% by weight of Prunus mume leaf aqueous extract, 0.01 to 15% by weight of isohexadecane, 0.01 to 10% by weight of dimethicone, 1 to 10% by weight of aluminum starch octenyl succinate, and 0.01 to 3% by weight of caprylic/capric triglyceride,

and optionally one or more of 0.00001 to 0.01% by weight of Opuntia tuna fruit extract, 0.00001 to 0.1% by weight of malachite extract, 0.001 to 1% by weight of adenosine, 0.001 to 1% by weight of algae extract, or 0.001 to 3% by weight of Opuntia ficus-indica fruit extract.