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Hemodialysis system having a flow path with a controlled compliant volume

  • US 10,722,636 B2
  • Filed: 10/19/2015
  • Issued: 07/28/2020
  • Est. Priority Date: 08/02/2011
  • Status: Active Grant
First Claim
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1. A system for performing dialysis, comprising:

  • a controlled compliant dialysis circuit;

    a dialyzer having a dialysis membrane, the dialyzer in fluid connection to the controlled compliant dialysis circuit;

    a sorbent cartridge for removing at least one impurity or waste species from a fluid, the sorbent cartridge in fluid connection with the controlled compliant dialysis circuit; and

    a microbial filter having an inlet in fluid connection with the controlled compliant dialysis circuit and an outlet in fluid connection with the dialyzer, wherein the microbial filter is configured to remove bacteria and endotoxins from dialysate in the controlled compliant dialysis circuit;

    wherein the microbial filter is positioned in the controlled compliant dialysis circuit;

    an extracorporeal circuit comprising a conduit for receiving blood from a subject and a conduit for returning blood to the subject, and a blood pump for conveying blood from the subject, to the dialyzer and back to the subject;

    at least one ultrafiltrate pump for moving fluid between the dialysis circuit and the extracorporeal circuit and an ultrafiltrate reservoir, wherein a flux of fluid moving between the extracorporeal circuit and the dialysis circuit is changed by the rate at which the ultrafiltrate pump is operating;

    wherein the at least one ultrafiltrate pump is configured to provide selective adjustment of the volume of the controlled compliant dialysis circuit by;

    (A) operating in an influx direction so that fluid moves from the ultrafiltrate reservoir to the controlled compliance dialysis circuit; and

    (B) operating in an efflux direction so that fluid moves from the controlled compliant dialysis circuit into the ultrafiltrate reservoir;

    wherein controlled compliance of the controlled compliant dialysis circuit is achieved by actively controlling, via one or more controllers, the influx and efflux of fluid to and from both the dialysis circuit and the extracorporeal circuit;

    wherein the system provides fluid balancing by using the at least one ultrafiltrate pump without the use of scales or balancing chambers.

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