Compact auto-injector

• US 10,722,653 B2
• Filed: 05/23/2019
• Issued: 07/28/2020
• Est. Priority Date: 08/30/2017
• Status: Active Grant

• Current Assignee: Pirouette Medical Incorporated
• Original Assignee: Pirouette Medical LLC
• Inventors: Kapas, Elijah, Kane, Matthew, Cullinane, Conor
• Primary Examiner(s): Shah, Nilay J
• Application Number:
  US16/420,738
• Publication Number:
  US 20190275252A1
• Time in Patent Office: 432 Days
• CPC Class Codes: A61M 2005/14284 with needle insertion means
• CPC Class Codes: A61M 2005/206 With automatic needle insertion
• CPC Class Codes: A61M 2005/2073 preventing premature release, e.g. by making use of a safety lock
• CPC Class Codes: A61M 2005/2474 with movable piercing means, e.g. ampoule remains fixed or steady
• CPC Class Codes: A61M 5/14244 adapted to be carried by the patient, e.g. portable on the body
• CPC Class Codes: A61M 5/14248 of the skin patch type
• CPC Class Codes: A61M 5/20 Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically A61M5/142 , A61M5/46 take precedence; hypodermic projectiles F42B12/54
• CPC Class Codes: A61M 5/2033 Spring-loaded one-shot injectors with or without automatic needle insertion multishot dosing syringes A61M5/31525, needle insertion only A61M5/3287
• CPC Class Codes: A61M 5/24 Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic ampoules or carpules A61J1/06
• CPC Class Codes: A61M 5/2466 by piercing without internal pressure increase A61M5/2429 takes precedence
• CPC Class Codes: A61M 5/31565 Administration mechanisms, i.e. constructional features, modes of administering a dose dosing mechanisms for setting a dose A61M5/31533
• CPC Class Codes: A61M 5/31571 Means preventing accidental administration for automatic syringes A61M5/20
• CPC Class Codes: A61M 5/3158 performed by axially moving actuator operated by user, e.g. an injection button
• CPC Class Codes: A61M 5/3202 Devices for protection of the needle before use, e.g. caps A61M5/50 takes precedence; for infusion spikes A61M5/1626; protectors for sharps A61B50/3001
• CPC Class Codes: A61M 5/3232 Semi-automatic needle retraction, i.e. in which triggering of the needle retraction requires a deliberate action by the user, e.g. manual release of spring-biased retraction means
• CPC Class Codes: A61M 5/46 having means for controlling depth of insertion

Abstract

A novel single use auto-injector for delivering a fixed amount of medicament is described. The auto-injector may include a sealed housing rotatably held in a cover. Once the auto-injector is positioned at the injection location, the user can transition the housing from a locked to an armed position. The user can then compress the sealed housing into the cover, triggering activation mechanisms that initiate the injection. A first activation mechanism engages an interlock to prevent reuse of the auto-injector. A second activation mechanism straightens and extends a curved needle to a set the exposed needle length. A third activation mechanism pierces a sealed reservoir allowing the medicament to be forced through the injection needle. Following the injection, the auto-injector expands and interlocks, retracting the needle into the auto-injector and preventing reuse.

Claims

1. A compact auto-injector device for delivering a medicament dose to a user, the device comprising:

a housing retained in a cover and adapted to be displaced relative to the cover from an initial position to an armed position, wherein a height of the device in the armed position is greater than the height of the device in the initial position;

a medicament reservoir disposed in the housing adapted to contain the medicament dose, the medicament reservoir having a longitudinal axis disposed parallel to an injection contact surface of the housing that contacts an injection surface of the user during delivery of the medicament dose; and

a needle extension system comprising an injection needle coupleable to the medicament reservoir, the needle extension system adapted to automatically deploy the injection needle up to an intramuscular depth to facilitate dispensing of the medicament dose by the device to the user,

wherein the device comprises an aspect ratio of width to height in a range from 1 to 10 at a time of the delivery of the medicament dose to the user.

2. The device of claim 1, wherein the housing comprises a sealed disk rotatably retained in the cover.

3. The device of claim 2, further comprising a safety mechanism releasably attached to the housing and adapted to prevent inadvertent deployment of the injection needle.

4. The device of claim 3, wherein the safety mechanism comprises at least one protrusion adapted to prevent disengagement of a locking mechanism of the needle extension system.

5. The device of claim 3, wherein the cover comprises a tactile surface adapted to contact the injection surface of the user, wherein the safety mechanism is further adapted to seal the tactile surface.

6. The device of claim 2, wherein the sealed disk is hermetically sealed to provide an environmentally tight internal environment of the sealed disk.

7. The device of claim 6, wherein the internal environment comprises a different characteristic than ambient.

8. The device of claim 7, wherein the characteristic comprises pressure.

9. The device of claim 2, wherein the housing forms an aperture adapted to allow the injection needle to pass therethrough upon deployment, wherein the sealed disk comprises a seal blocking the aperture.

10. The device of claim 9, wherein the seal is adapted to allow the injection needle to pass therethrough without blocking a lumen of the injection needle.

11. The device of claim 1, wherein the device further comprises an inspection feature related to status of the device.

12. The device of claim 11, wherein the inspection feature comprises a viewing window into an internal portion of the device for medicament inspection.

13. The device of claim 1, wherein the housing comprises a power supply and an electronic component adapted to provide feedback to the user selected from the group consisting of an audible feedback, a visual feedback, a tactile feedback, and combinations thereof.

14. The device of claim 13, wherein the electronic component is adapted to communicate with an external smart device.

15. The device of claim 1, wherein the needle extension system further comprises a needle barrel and a needle barrel cap for supporting the injection needle.

16. The device of claim 15, wherein the needle barrel is adapted to displace both angularly and axially during deployment of the injection needle.

17. The device of claim 15, wherein the needle extension system further comprises at least one spring adapted to displace the needle barrel.

18. The device of claim 17, wherein the at least one spring comprises two springs adapted to displace the needle barrel.

19. The device of claim 17, wherein the at least one spring comprises a torsion spring.

20. The device of claim 1, wherein the device is adapted to deliver the medicament dose to the user in a total injection time of no more than 15 seconds.

21. A method of operating a compact simile use auto-injector device for delivering a medicament dose to a user, the method comprising the steps of:

grasping the device comprising;

a housing retained in a cover and adapted to be displaced relative to the cover from an initial position to an armed position, wherein a height of the device in the armed position is greater than the height of the device in the initial position;

a medicament reservoir disposed in the housing adapted to contain the medicament dose, the medicament reservoir having a longitudinal axis disposed parallel to an injection contact surface of the housing that contacts an injection surface of the user during delivery of the medicament dose;

a needle extension system comprising an injection needle coupleable to the medicament reservoir, the needle extension system adapted to automatically deploy the injection needle up to an intramuscular depth to facilitate dispensing of the medicament dose by the device to the user; and

an aspect ratio of width to height in a range from 1 to 10 at a time of the delivery of the medicament dose to the user;

adhering the device to the injection surface at a desired injection location;

triggering automatic deployment of the injection needle,

dispensing the medicament dose through the injection needle; and

thereafter, immediately removing the device from the injection surface.

22. The method of claim 21, wherein the housing comprises a sealed disk rotatably retained in the cover.

23. The method of claim 22, wherein the sealed disk is hermetically sealed to provide an environmentally tight interior.

24. The method of claim 22, wherein the housing forms an aperture adapted to allow the injection needle to pass therethrough upon the deployment, wherein the sealed disk comprises a seal blocking the aperture.

25. The method of claim 21, wherein the device comprises the needle extension system comprising a needle barrel and a needle barrel cap for supporting the injection needle.

26. The method of claim 25, wherein the step of triggering deployment of the injection needle comprises displacing the needle barrel both angularly and axially.

27. The method of claim 21, wherein the housing comprises a power supply and an electronic component, wherein the method further comprises receiving feedback from the electronic component selected from the group consisting of an audible feedback, a visual feedback, a tactile feedback, and combinations thereof.

28. The method of claim 27, wherein the electronic component is adapted to communicate with an external smart device.

29. The method of claim 21, further comprising the step of removing a safety mechanism from the housing prior to triggering the deployment of the injection needle to the user.

30. The method of claim 29, further comprising the step of disengaging a locking mechanism of the needle extension system after the step of removing the safety mechanism.

31. The method of claim 21, wherein the device comprises an inspection feature related to status of the device.

32. The method of claim 21, wherein the step of dispensing the medicament dose through the injection needle comprises a total injection time of no more than 15 seconds.