Acid-solubilized copper-ammonium complexes and copper-zinc ammonium complexes, compositions, preparations, methods, and uses

• US 10,729,139 B2
• Filed: 12/12/2014
• Issued: 08/04/2020
• Est. Priority Date: 12/13/2013
• Status: Active Grant

• Current Assignee: VM Agritech Limited
• Original Assignee: Myco Sciences Limited
• Inventors: Hall, Tony John
• Primary Examiner(s): Roney, Celeste A
• Application Number:
  US15/103,872
• Publication Number:
  US 20160309722A1
• Time in Patent Office: 2,062 Days
• Field of Search: None
• CPC Class Codes: A01N 25/02 containing liquids as carriers, diluents or solvents
• CPC Class Codes: A01N 25/04 Dispersions, emulsions, suspoemulsions, suspension concentrates or gels foams A01N25/16
• CPC Class Codes: A01N 59/16 Heavy metals; Compounds thereof
• CPC Class Codes: A01N 59/20 Copper
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 33/02 Ammonia; Compounds thereof
• CPC Class Codes: A61K 33/30 Zinc; Compounds thereof
• CPC Class Codes: A61K 33/34 Copper; Compounds thereof
• CPC Class Codes: A61K 47/02 Inorganic compounds
• CPC Class Codes: A61K 47/12 Carboxylic acids; Salts or anhydrides thereof
• CPC Class Codes: A61K 47/36 Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
• CPC Class Codes: A61K 8/042 Gels
• CPC Class Codes: A61K 8/19 containing inorganic ingredients
• CPC Class Codes: A61K 8/27 Zinc; Compounds thereof
• CPC Class Codes: A61K 9/0014 Skin, i.e. galenical aspects of topical compositions non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00
• CPC Class Codes: A61K 9/06 Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels composition of ointments, creams or gels A61K47/00
• CPC Class Codes: A61P 31/02 Local antiseptics
• CPC Class Codes: A61Q 19/00 Preparations for care of the skin
• CPC Class Codes: C02F 1/50 by addition or application of a germicide or by oligodynamic treatment C02F1/4606, C02F1/467, C02F1/76 take precedence
• CPC Class Codes: C02F 2103/42 from bathing facilities, e.g. swimming pools
• CPC Class Codes: Y02A 50/30 : Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

An antimicrobial composition is disclosed that contains an acid-solubilized copper ammonium or copper-zinc ammonium complex that is effective against microorganisms such as nosocomial or environmental bacteria, fungi, viruses, and the like. The antimicrobial composition can be used in the preparation of a medicament for treating microbes or a microbial infection, and may contain a carrier to create a cream, soap, wash, spray, dressing, cleanser, cosmetic product, topical drug product, or other antimicrobial product.

Claims

1. An antimicrobial composition produced by the process of:

combining 10-160 grams/liter of hydrated copper sulfate with water;

stirring the combined mixture and adding 20-32 milliliters/liter of an ammonium hydroxide solution to the resulting mixture to generate an insoluble copper-ammonium complex; and

adding a water soluble acid selected from the group consisting of phosphorous acid and phosphoric acid to the copper-ammonium complex to solubilize the copper-ammonium complex and to control the pH of the clear blue solution thus formed;

wherein the concentration of elemental copper in the clear blue solution is between 15 and 40 grams/liter, wherein when present the amount of phosphorous acid is 24-50 grams/liter and wherein when present the amount of phosphoric acid is 17-85 grams/liter, the resulting composition having synergistic antimicrobial properties greater than the antimicrobial properties of each constituent component.

2. The antimicrobial composition of claim 1, wherein the water is selected from the group consisting of distilled water, deionized water, purified water, filtered water, pharmaceutical grade water, medical grade water, and reverse osmosis water.

3. The antimicrobial composition of claim 1 wherein the hydrated copper sulfate solution further comprises 2.5-15 grams/liter of elemental zinc from a zinc salt in solution forming a copper-zinc-ammonium complex upon the addition of the ammonium hydroxide solution.

4. The antimicrobial composition of claim 3, wherein the zinc salt is selected from the group consisting of anhydrous or hydrated zinc sulfate.

5. The antimicrobial composition of claim 1, further comprising auxiliaries, adjuvants, carriers, surfactants, coating agents or extenders.

6. The antimicrobial composition of claim 1, further comprising a carrier selected from the group consisting of a gel, an ointment, an oil, a paste, a medicament, a sprayable solution, a dressing solution, an irrigation solution, a cream, a soap, a detergent, a wash, and a foam.

7. A method of producing an antimicrobial composition comprising the steps of:

combining 10-160 grams/liter of hydrated copper sulfate with water;

stirring the combined hydrated copper sulfate and water mixture;

adding 20-32 milliliters/liter of ammonium hydroxide solution to the resulting mixture to generate an insoluble copper-ammonium complex; and

adding a water soluble acid selected from the group consisting of phosphorous acid and phosphoric acid to the copper-ammonium complex to solubilize the copper-ammonium complex and to control the pH of the clear blue antimicrobial composition thus formed;

wherein the concentration of elemental copper in the clear blue solution is between 15 and 40 grams/liter, wherein when present the amount of phosphorous acid is 24-50 grams/liter and wherein when present the amount of phosphoric acid is 17-85 grams/liter;

the resulting composition having synergistic antimicrobial properties greater than the antimicrobial properties of each constituent component.

8. A method comprising applying to at least one of a living organism or an environment communicable therewith an effective amount of a liquid including a diluted solution of an anti-microbial composition comprising an acid-solubilized metal-ammonium complex and a water soluble acid added thereto;

the water soluble acid selected from the group consisting of phosphorous acid and phosphoric acid, and added to the copper-ammonium complex to solubilize the copper-ammonium complex and to control the pH of the clear blue solution thus formed;

wherein the metal-ammonium complex is selected from copper-ammonium complex, zinc ammonium complex, and combinations of copper-ammonium and zinc-ammonium complex, wherein when present the concentration of elemental copper in the diluted solution is between 0.15 and 0.4 grams/liter, wherein when present the concentration of elemental zinc in the diluted solution is between 0.025 and 0.15 grams/liter, wherein when present the amount of phosphorous acid is 0.24 and 0.5 grams/liter and wherein when present the amount of phosphoric acid is between 0.17 and 0.85 grams/liter, the resulting composition having synergistic antimicrobial properties greater than the antimicrobial properties of each constituent component.

9. The method of claim 8, wherein the metal-ammonium complex is copper-ammonium complex.

10. The method of claim 8, wherein the metal-ammonium complex is zinc-ammonium complex.

11. The method of claim 8, wherein the metal-ammonium complex is copper-zinc-ammonium complex.

12. The method of claim 8, wherein the living organism is a plant, and the method comprises applying the anti-microbial composition as a spray to at least one of a seed, flower, foliage, or environment of the plant.

13. The method of claim 8, wherein the living organism includes skin tissue, and the skin tissue or the environment communicable therewith.

14. An antimicrobial soluble copper composition comprising:

a solution comprising 10-160 grams/liter hydrated copper sulfate;

ammonium hydroxide added to the hydrated copper sulfate solution at 20-32 milliliters/liter to generate an insoluble copper-ammonium complex; and

at least one water soluble acid selected from the group consisting of phosphorous acid and phosphoric acid added to the hydrated copper sulfate solution to solubilize the copper-ammonium complex and to control the pH of the clear blue acid-solubilized copper-ammonium solution thus formed;

wherein the concentration of elemental copper in the clear blue solution is between 15 and 40 grams/liter, wherein when present the amount of phosphorous acid is 24-50 grams/liter and wherein when present the amount of phosphoric acid is 17-85 grams/liter;

the resulting composition having synergistic antimicrobial properties greater than the antimicrobial properties of each constituent component.

15. The antimicrobial composition of claim 14, wherein the water is selected from the group consisting of distilled water, deionized water, purified water, filtered water, pharmaceutical grade water, medical grade water, and reverse osmosis water.

16. The antimicrobial composition of claim 14, wherein the hydrated copper sulfate solution further comprises 2.5-15 grams/liter of elemental zinc from a zinc salt in solution forming a copper-zinc-ammonium complex upon the addition of the ammonium hydroxide solution.

17. The antimicrobial composition of claim 16, wherein the zinc salt is selected from the group consisting of anhydrous or hydrated zinc sulfate.

18. The antimicrobial composition of claim 14, further comprising auxiliaries, adjuvants, carriers, surfactants, coating agents or extenders.

19. The antimicrobial composition of claim 14, further comprising a carrier selected from the group consisting of a gel, an ointment, an oil, a paste, a medicament, a sprayable solution, a dressing solution, an irrigation solution, a cream, a soap, a detergent, a wash, and a foam.