Chimeric antigen receptors targeting GPC3 and uses thereof

  • US 10,731,127 B2
  • Filed: 05/06/2014
  • Issued: 08/04/2020
  • Est. Priority Date: 05/08/2013
  • Status: Active Grant
First Claim
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1. A nucleic acid encoding a chimeric antigen receptor targeting glypican-3 (GPC3) for expressing at a surface of a human T lymphocyte, wherein the chimeric antigen receptor targeting GPC3 comprises, connected in an order of, an extracellular binding domain, a transmembrane region, and an intracellular signaling domain, wherein the extracellular binding domain comprises a single chain antibody scFv(GPC3) which specifically recognizes a C-terminal epitope of GPC3, and wherein the chimeric antigen receptor comprises SEQ ID NO:

  • 25.

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