Pharmaceutical oil-in-water nano-emulsion

  • US 10,736,842 B2
  • Filed: 06/25/2015
  • Issued: 08/11/2020
  • Est. Priority Date: 06/25/2014
  • Status: Active Grant
First Claim
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1. A pharmaceutical oil-in-water nano-emulsion composition, comprising:

  • a pharmaceutically active substance, encased in monounsaturated fatty acid droplets, wherein said monounsaturated fatty acid is present in an amount of about 5-25% w/w based on the weight of the total compositionsaid droplets having an average particle size in the range of 60 to 200 nm;

    a non-ionic surfactant system comprising a mixture of polyethers, macrogolglycerides and polysaccharideswherein the polyethers are present in an amount ranging from about 2-25% w/w based on the total weight of the composition,wherein the macrogolglycerides are present in an amount ranging from 10-30% w/w based on the total weight of the composition,wherein the polysaccharides are present in an amount ranging from 2-30% w/w based on the total weight of the composition;

    water present in an amount of between 15 and 50% w/w; and

    pharmaceutically acceptable adjuvants,wherein the composition is highly stable having a drug loading capacity of the pharmaceutically active substance of up to 100 mg/mL.

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